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Evaluation of Intra-Abdominal Hypertension Parameters in Patients with Acute Pancreatitis

Background: Patients with acute pancreatitis develop numerous complications and organ damage due to increased intra-abdominal pressure (IAP). These extrapancreatic complications determine the clinical outcome of the disease. Materials and methods: A total of 100 patients with acute pancreatitis were...

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Autores principales: Stojanović, Maja, Đurić, Marko, Nenadić, Irina, Dimić, Nemanja, Bojić, Suzana, Stevanović, Predrag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304430/
https://www.ncbi.nlm.nih.gov/pubmed/37374010
http://dx.doi.org/10.3390/life13061227
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author Stojanović, Maja
Đurić, Marko
Nenadić, Irina
Dimić, Nemanja
Bojić, Suzana
Stevanović, Predrag
author_facet Stojanović, Maja
Đurić, Marko
Nenadić, Irina
Dimić, Nemanja
Bojić, Suzana
Stevanović, Predrag
author_sort Stojanović, Maja
collection PubMed
description Background: Patients with acute pancreatitis develop numerous complications and organ damage due to increased intra-abdominal pressure (IAP). These extrapancreatic complications determine the clinical outcome of the disease. Materials and methods: A total of 100 patients with acute pancreatitis were included in the prospective cohort study. Observed patients were divided into two groups according to their mean values of IAP (normal IAP values and elevated IAP values), which were compared with examined variables. Patients with intra-abdominal hypertension (IAH) were divided into four groups by IAP values, and those groups of patients were also compared with the examined variables. Results: Differences between body mass index (BMI) (p = 0.001), lactates (p = 0.006), and the Sequential Organ Failure Assessment (SOFA) score (p = 0.001) were statistically significant within all examined IAH groups. Differences between the mean arterial pressure (MAP) (p = 0.012) and filtration gradient (FG) (p < 0.001) were statistically significant between the first and second IAH groups in relation to the fourth. Differences in diuresis per hour (p = 0.022) showed statistical significance in relation to the first and third groups of IAH patients. Conclusions: Changes in IAP values lead to changes in basic vital parameters MAP, APP, FG, diuresis per hour, and lactate levels in patients with acute pancreatitis. Early recognition of changes in the SOFA score accompanying an increase in the IAP value is essential.
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spelling pubmed-103044302023-06-29 Evaluation of Intra-Abdominal Hypertension Parameters in Patients with Acute Pancreatitis Stojanović, Maja Đurić, Marko Nenadić, Irina Dimić, Nemanja Bojić, Suzana Stevanović, Predrag Life (Basel) Article Background: Patients with acute pancreatitis develop numerous complications and organ damage due to increased intra-abdominal pressure (IAP). These extrapancreatic complications determine the clinical outcome of the disease. Materials and methods: A total of 100 patients with acute pancreatitis were included in the prospective cohort study. Observed patients were divided into two groups according to their mean values of IAP (normal IAP values and elevated IAP values), which were compared with examined variables. Patients with intra-abdominal hypertension (IAH) were divided into four groups by IAP values, and those groups of patients were also compared with the examined variables. Results: Differences between body mass index (BMI) (p = 0.001), lactates (p = 0.006), and the Sequential Organ Failure Assessment (SOFA) score (p = 0.001) were statistically significant within all examined IAH groups. Differences between the mean arterial pressure (MAP) (p = 0.012) and filtration gradient (FG) (p < 0.001) were statistically significant between the first and second IAH groups in relation to the fourth. Differences in diuresis per hour (p = 0.022) showed statistical significance in relation to the first and third groups of IAH patients. Conclusions: Changes in IAP values lead to changes in basic vital parameters MAP, APP, FG, diuresis per hour, and lactate levels in patients with acute pancreatitis. Early recognition of changes in the SOFA score accompanying an increase in the IAP value is essential. MDPI 2023-05-23 /pmc/articles/PMC10304430/ /pubmed/37374010 http://dx.doi.org/10.3390/life13061227 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stojanović, Maja
Đurić, Marko
Nenadić, Irina
Dimić, Nemanja
Bojić, Suzana
Stevanović, Predrag
Evaluation of Intra-Abdominal Hypertension Parameters in Patients with Acute Pancreatitis
title Evaluation of Intra-Abdominal Hypertension Parameters in Patients with Acute Pancreatitis
title_full Evaluation of Intra-Abdominal Hypertension Parameters in Patients with Acute Pancreatitis
title_fullStr Evaluation of Intra-Abdominal Hypertension Parameters in Patients with Acute Pancreatitis
title_full_unstemmed Evaluation of Intra-Abdominal Hypertension Parameters in Patients with Acute Pancreatitis
title_short Evaluation of Intra-Abdominal Hypertension Parameters in Patients with Acute Pancreatitis
title_sort evaluation of intra-abdominal hypertension parameters in patients with acute pancreatitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304430/
https://www.ncbi.nlm.nih.gov/pubmed/37374010
http://dx.doi.org/10.3390/life13061227
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