Cargando…

A Miniature Multi-Functional Photoacoustic Probe

Photoacoustic technology is a promising tool to provide morphological and functional information in biomedical research. To enhance the imaging efficiency, the reported photoacoustic probes have been designed coaxially involving complicated optical/acoustic prisms to bypass the opaque piezoelectric...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Riqiang, Zhang, Jiaming, Gao, Wen, Wang, Xiatian, Lv, Shengmiao, Lam, Kwok-Ho, Gong, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304571/
https://www.ncbi.nlm.nih.gov/pubmed/37374854
http://dx.doi.org/10.3390/mi14061269
_version_ 1785065542206357504
author Lin, Riqiang
Zhang, Jiaming
Gao, Wen
Wang, Xiatian
Lv, Shengmiao
Lam, Kwok-Ho
Gong, Xiaojing
author_facet Lin, Riqiang
Zhang, Jiaming
Gao, Wen
Wang, Xiatian
Lv, Shengmiao
Lam, Kwok-Ho
Gong, Xiaojing
author_sort Lin, Riqiang
collection PubMed
description Photoacoustic technology is a promising tool to provide morphological and functional information in biomedical research. To enhance the imaging efficiency, the reported photoacoustic probes have been designed coaxially involving complicated optical/acoustic prisms to bypass the opaque piezoelectric layer of ultrasound transducers, but this has led to bulky probes and has hindered the applications in limited space. Though the emergence of transparent piezoelectric materials helps to save effort on the coaxial design, the reported transparent ultrasound transducers were still bulky. In this work, a miniature photoacoustic probe with an outer diameter of 4 mm was developed, in which an acoustic stack was made with a combination of transparent piezoelectric material and a gradient-index lens as a backing layer. The transparent ultrasound transducer exhibited a high center frequency of ~47 MHz and a −6 dB bandwidth of 29.4%, which could be easily assembled with a pigtailed ferrule of a single-mode fiber. The multi-functional capability of the probe was successfully validated through experiments of fluid flow sensing and photoacoustic imaging.
format Online
Article
Text
id pubmed-10304571
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103045712023-06-29 A Miniature Multi-Functional Photoacoustic Probe Lin, Riqiang Zhang, Jiaming Gao, Wen Wang, Xiatian Lv, Shengmiao Lam, Kwok-Ho Gong, Xiaojing Micromachines (Basel) Communication Photoacoustic technology is a promising tool to provide morphological and functional information in biomedical research. To enhance the imaging efficiency, the reported photoacoustic probes have been designed coaxially involving complicated optical/acoustic prisms to bypass the opaque piezoelectric layer of ultrasound transducers, but this has led to bulky probes and has hindered the applications in limited space. Though the emergence of transparent piezoelectric materials helps to save effort on the coaxial design, the reported transparent ultrasound transducers were still bulky. In this work, a miniature photoacoustic probe with an outer diameter of 4 mm was developed, in which an acoustic stack was made with a combination of transparent piezoelectric material and a gradient-index lens as a backing layer. The transparent ultrasound transducer exhibited a high center frequency of ~47 MHz and a −6 dB bandwidth of 29.4%, which could be easily assembled with a pigtailed ferrule of a single-mode fiber. The multi-functional capability of the probe was successfully validated through experiments of fluid flow sensing and photoacoustic imaging. MDPI 2023-06-19 /pmc/articles/PMC10304571/ /pubmed/37374854 http://dx.doi.org/10.3390/mi14061269 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Lin, Riqiang
Zhang, Jiaming
Gao, Wen
Wang, Xiatian
Lv, Shengmiao
Lam, Kwok-Ho
Gong, Xiaojing
A Miniature Multi-Functional Photoacoustic Probe
title A Miniature Multi-Functional Photoacoustic Probe
title_full A Miniature Multi-Functional Photoacoustic Probe
title_fullStr A Miniature Multi-Functional Photoacoustic Probe
title_full_unstemmed A Miniature Multi-Functional Photoacoustic Probe
title_short A Miniature Multi-Functional Photoacoustic Probe
title_sort miniature multi-functional photoacoustic probe
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304571/
https://www.ncbi.nlm.nih.gov/pubmed/37374854
http://dx.doi.org/10.3390/mi14061269
work_keys_str_mv AT linriqiang aminiaturemultifunctionalphotoacousticprobe
AT zhangjiaming aminiaturemultifunctionalphotoacousticprobe
AT gaowen aminiaturemultifunctionalphotoacousticprobe
AT wangxiatian aminiaturemultifunctionalphotoacousticprobe
AT lvshengmiao aminiaturemultifunctionalphotoacousticprobe
AT lamkwokho aminiaturemultifunctionalphotoacousticprobe
AT gongxiaojing aminiaturemultifunctionalphotoacousticprobe
AT linriqiang miniaturemultifunctionalphotoacousticprobe
AT zhangjiaming miniaturemultifunctionalphotoacousticprobe
AT gaowen miniaturemultifunctionalphotoacousticprobe
AT wangxiatian miniaturemultifunctionalphotoacousticprobe
AT lvshengmiao miniaturemultifunctionalphotoacousticprobe
AT lamkwokho miniaturemultifunctionalphotoacousticprobe
AT gongxiaojing miniaturemultifunctionalphotoacousticprobe