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Predictors of Short-Term Mortality in Patients with Ischemic Stroke

Background and Objectives: The purpose of this study is to investigate the predictive factors for intrahospital mortality in ischemic stroke patients. We will examine the association between a range of clinical and demographic factors and intrahospital mortality, including age, sex, comorbidities, l...

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Autores principales: Iluţ, Silvina, Vesa, Ştefan Cristian, Văcăraș, Vitalie, Mureșanu, Dafin-Fior
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304635/
https://www.ncbi.nlm.nih.gov/pubmed/37374346
http://dx.doi.org/10.3390/medicina59061142
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author Iluţ, Silvina
Vesa, Ştefan Cristian
Văcăraș, Vitalie
Mureșanu, Dafin-Fior
author_facet Iluţ, Silvina
Vesa, Ştefan Cristian
Văcăraș, Vitalie
Mureșanu, Dafin-Fior
author_sort Iluţ, Silvina
collection PubMed
description Background and Objectives: The purpose of this study is to investigate the predictive factors for intrahospital mortality in ischemic stroke patients. We will examine the association between a range of clinical and demographic factors and intrahospital mortality, including age, sex, comorbidities, laboratory values, and medication use. Materials and Methods: This retrospective, longitudinal, analytic, observational cohort study included 243 patients over 18 years old with a new ischemic stroke diagnosis who were hospitalized in Cluj-Napoca Emergency County Hospital. Data collected included the patient demographics, baseline characteristics at hospital admission, medication use, carotid artery Doppler ultrasound, as well as cardiology exam, and intrahospital death. Results: Multivariate logistic regression was used to determine which variables were independently associated with intrahospital death. An NIHSS score > 9 (OR—17.4; p < 0.001) and a lesion volume > 22.3 mL (OR—5.8; p = 0.003) were found to be associated with the highest risk of death. In contrast antiplatelet treatment (OR—0.349; p = 0.04) was associated with lower mortality rates. Conclusions: Our study identified a high NIHSS score and large lesion volume as independent risk factors for intrahospital mortality in ischemic stroke patients. Antiplatelet therapy was associated with lower mortality rates. Further studies are needed to explore the potential mechanisms underlying these associations and to develop targeted interventions to improve patient outcomes.
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spelling pubmed-103046352023-06-29 Predictors of Short-Term Mortality in Patients with Ischemic Stroke Iluţ, Silvina Vesa, Ştefan Cristian Văcăraș, Vitalie Mureșanu, Dafin-Fior Medicina (Kaunas) Article Background and Objectives: The purpose of this study is to investigate the predictive factors for intrahospital mortality in ischemic stroke patients. We will examine the association between a range of clinical and demographic factors and intrahospital mortality, including age, sex, comorbidities, laboratory values, and medication use. Materials and Methods: This retrospective, longitudinal, analytic, observational cohort study included 243 patients over 18 years old with a new ischemic stroke diagnosis who were hospitalized in Cluj-Napoca Emergency County Hospital. Data collected included the patient demographics, baseline characteristics at hospital admission, medication use, carotid artery Doppler ultrasound, as well as cardiology exam, and intrahospital death. Results: Multivariate logistic regression was used to determine which variables were independently associated with intrahospital death. An NIHSS score > 9 (OR—17.4; p < 0.001) and a lesion volume > 22.3 mL (OR—5.8; p = 0.003) were found to be associated with the highest risk of death. In contrast antiplatelet treatment (OR—0.349; p = 0.04) was associated with lower mortality rates. Conclusions: Our study identified a high NIHSS score and large lesion volume as independent risk factors for intrahospital mortality in ischemic stroke patients. Antiplatelet therapy was associated with lower mortality rates. Further studies are needed to explore the potential mechanisms underlying these associations and to develop targeted interventions to improve patient outcomes. MDPI 2023-06-13 /pmc/articles/PMC10304635/ /pubmed/37374346 http://dx.doi.org/10.3390/medicina59061142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iluţ, Silvina
Vesa, Ştefan Cristian
Văcăraș, Vitalie
Mureșanu, Dafin-Fior
Predictors of Short-Term Mortality in Patients with Ischemic Stroke
title Predictors of Short-Term Mortality in Patients with Ischemic Stroke
title_full Predictors of Short-Term Mortality in Patients with Ischemic Stroke
title_fullStr Predictors of Short-Term Mortality in Patients with Ischemic Stroke
title_full_unstemmed Predictors of Short-Term Mortality in Patients with Ischemic Stroke
title_short Predictors of Short-Term Mortality in Patients with Ischemic Stroke
title_sort predictors of short-term mortality in patients with ischemic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304635/
https://www.ncbi.nlm.nih.gov/pubmed/37374346
http://dx.doi.org/10.3390/medicina59061142
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