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Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents
In recent decades, magnetic nanoparticles (MNPs) have attracted considerable research interest as versatile substances for various biomedical applications, particularly as contrast agents in magnetic resonance imaging (MRI). Depending on their composition and particle size, most MNPs are either para...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304637/ https://www.ncbi.nlm.nih.gov/pubmed/37376193 http://dx.doi.org/10.3390/pharmaceutics15061745 |
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author | Tegafaw, Tirusew Liu, Shuwen Ahmad, Mohammad Yaseen Saidi, Abdullah Khamis Ali Al Zhao, Dejun Liu, Ying Nam, Sung-Wook Chang, Yongmin Lee, Gang Ho |
author_facet | Tegafaw, Tirusew Liu, Shuwen Ahmad, Mohammad Yaseen Saidi, Abdullah Khamis Ali Al Zhao, Dejun Liu, Ying Nam, Sung-Wook Chang, Yongmin Lee, Gang Ho |
author_sort | Tegafaw, Tirusew |
collection | PubMed |
description | In recent decades, magnetic nanoparticles (MNPs) have attracted considerable research interest as versatile substances for various biomedical applications, particularly as contrast agents in magnetic resonance imaging (MRI). Depending on their composition and particle size, most MNPs are either paramagnetic or superparamagnetic. The unique, advanced magnetic properties of MNPs, such as appreciable paramagnetic or strong superparamagnetic moments at room temperature, along with their large surface area, easy surface functionalization, and the ability to offer stronger contrast enhancements in MRI, make them superior to molecular MRI contrast agents. As a result, MNPs are promising candidates for various diagnostic and therapeutic applications. They can function as either positive (T(1)) or negative (T(2)) MRI contrast agents, producing brighter or darker MR images, respectively. In addition, they can function as dual-modal T(1) and T(2) MRI contrast agents, producing either brighter or darker MR images, depending on the operational mode. It is essential that the MNPs are grafted with hydrophilic and biocompatible ligands to maintain their nontoxicity and colloidal stability in aqueous media. The colloidal stability of MNPs is critical in order to achieve a high-performance MRI function. Most of the MNP-based MRI contrast agents reported in the literature are still in the developmental stage. With continuous progress being made in the detailed scientific research on them, their use in clinical settings may be realized in the future. In this study, we present an overview of the recent developments in the various types of MNP-based MRI contrast agents and their in vivo applications. |
format | Online Article Text |
id | pubmed-10304637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103046372023-06-29 Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents Tegafaw, Tirusew Liu, Shuwen Ahmad, Mohammad Yaseen Saidi, Abdullah Khamis Ali Al Zhao, Dejun Liu, Ying Nam, Sung-Wook Chang, Yongmin Lee, Gang Ho Pharmaceutics Review In recent decades, magnetic nanoparticles (MNPs) have attracted considerable research interest as versatile substances for various biomedical applications, particularly as contrast agents in magnetic resonance imaging (MRI). Depending on their composition and particle size, most MNPs are either paramagnetic or superparamagnetic. The unique, advanced magnetic properties of MNPs, such as appreciable paramagnetic or strong superparamagnetic moments at room temperature, along with their large surface area, easy surface functionalization, and the ability to offer stronger contrast enhancements in MRI, make them superior to molecular MRI contrast agents. As a result, MNPs are promising candidates for various diagnostic and therapeutic applications. They can function as either positive (T(1)) or negative (T(2)) MRI contrast agents, producing brighter or darker MR images, respectively. In addition, they can function as dual-modal T(1) and T(2) MRI contrast agents, producing either brighter or darker MR images, depending on the operational mode. It is essential that the MNPs are grafted with hydrophilic and biocompatible ligands to maintain their nontoxicity and colloidal stability in aqueous media. The colloidal stability of MNPs is critical in order to achieve a high-performance MRI function. Most of the MNP-based MRI contrast agents reported in the literature are still in the developmental stage. With continuous progress being made in the detailed scientific research on them, their use in clinical settings may be realized in the future. In this study, we present an overview of the recent developments in the various types of MNP-based MRI contrast agents and their in vivo applications. MDPI 2023-06-15 /pmc/articles/PMC10304637/ /pubmed/37376193 http://dx.doi.org/10.3390/pharmaceutics15061745 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tegafaw, Tirusew Liu, Shuwen Ahmad, Mohammad Yaseen Saidi, Abdullah Khamis Ali Al Zhao, Dejun Liu, Ying Nam, Sung-Wook Chang, Yongmin Lee, Gang Ho Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents |
title | Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents |
title_full | Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents |
title_fullStr | Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents |
title_full_unstemmed | Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents |
title_short | Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents |
title_sort | magnetic nanoparticle-based high-performance positive and negative magnetic resonance imaging contrast agents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304637/ https://www.ncbi.nlm.nih.gov/pubmed/37376193 http://dx.doi.org/10.3390/pharmaceutics15061745 |
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