SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen

BACKGROUND: The duration and regimen of tuberculosis (TB) treatment is currently based predominantly on whether the M. tuberculosis (Mtb) strain is drug-sensitive (DS) or multidrug-resistant (MDR) with doses adjusted by patients’ weight only. The systematic stratification of patients for personalize...

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Detalles Bibliográficos
Autores principales: Arias, Lilibeth, Otwombe, Kennedy, Waja, Ziyaad, Tukvadze, Nestani, Korinteli, Tamta, Moloantoa, Tumelo, Fonseca, Kaori L, Pillay, Natasha, Seiphetlo, Thabiso, Ouchi-Vernet, Dan, Siles, Adrian, Carabias, Lidia, Quiñones, Carles, Vashakidze, Sergo, Martinson, Neil, Vilaplana, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304643/
https://www.ncbi.nlm.nih.gov/pubmed/37370174
http://dx.doi.org/10.1186/s13063-023-07448-0

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