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The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women

Background: The thesis on which this paper is based intended to investigate whether the result of the microbiological vaginal swab has an influence on the outcome of the fertility treatment. Methods: The microbiological vaginal swabs of patients who received fertility treatment at Saarland Universit...

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Autores principales: Findeklee, Sebastian, Urban, Lena, Sima, Romina-Marina, Baus, Simona Lucia, Halfmann, Alexander, Wagenpfeil, Gudrun, Solomayer, Erich-Franz, Haj Hamoud, Bashar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304662/
https://www.ncbi.nlm.nih.gov/pubmed/37374032
http://dx.doi.org/10.3390/life13061251
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author Findeklee, Sebastian
Urban, Lena
Sima, Romina-Marina
Baus, Simona Lucia
Halfmann, Alexander
Wagenpfeil, Gudrun
Solomayer, Erich-Franz
Haj Hamoud, Bashar
author_facet Findeklee, Sebastian
Urban, Lena
Sima, Romina-Marina
Baus, Simona Lucia
Halfmann, Alexander
Wagenpfeil, Gudrun
Solomayer, Erich-Franz
Haj Hamoud, Bashar
author_sort Findeklee, Sebastian
collection PubMed
description Background: The thesis on which this paper is based intended to investigate whether the result of the microbiological vaginal swab has an influence on the outcome of the fertility treatment. Methods: The microbiological vaginal swabs of patients who received fertility treatment at Saarland University Hospital were evaluated. Depending on the microorganisms detected, the swab result was classified as inconspicuous, intermediate, or conspicuous. The SPSS software was used to determine the correlation between the swab result and the outcome of the fertility treatment. Results: Dysbiosis was associated with a worse outcome of fertility treatment. The pregnancy rate with a conspicuous swab was 8.6%, whereas it was 13.4% with an inconspicuous swab. However, this association was not statistically significant. Furthermore, an association of endometriosis with dysbiosis was found. Endometriosis was more frequent with a conspicuous swab result than with an inconspicuous result (21.1% vs. 17.7%), yet the correlation was not statistically significant. However, the absence of lactobacilli was significantly associated with endometriosis (p = 0.021). The association between endometriosis and a lower pregnancy rate was also statistically significant (p = 0.006). Conclusion: The microbiological vaginal and cervical swabs can be used as predictors for the success of fertility treatments. Further studies are needed to assess the impact of transforming a dysbiotic flora into a eubiotic environment on the success of fertility treatments.
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spelling pubmed-103046622023-06-29 The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women Findeklee, Sebastian Urban, Lena Sima, Romina-Marina Baus, Simona Lucia Halfmann, Alexander Wagenpfeil, Gudrun Solomayer, Erich-Franz Haj Hamoud, Bashar Life (Basel) Article Background: The thesis on which this paper is based intended to investigate whether the result of the microbiological vaginal swab has an influence on the outcome of the fertility treatment. Methods: The microbiological vaginal swabs of patients who received fertility treatment at Saarland University Hospital were evaluated. Depending on the microorganisms detected, the swab result was classified as inconspicuous, intermediate, or conspicuous. The SPSS software was used to determine the correlation between the swab result and the outcome of the fertility treatment. Results: Dysbiosis was associated with a worse outcome of fertility treatment. The pregnancy rate with a conspicuous swab was 8.6%, whereas it was 13.4% with an inconspicuous swab. However, this association was not statistically significant. Furthermore, an association of endometriosis with dysbiosis was found. Endometriosis was more frequent with a conspicuous swab result than with an inconspicuous result (21.1% vs. 17.7%), yet the correlation was not statistically significant. However, the absence of lactobacilli was significantly associated with endometriosis (p = 0.021). The association between endometriosis and a lower pregnancy rate was also statistically significant (p = 0.006). Conclusion: The microbiological vaginal and cervical swabs can be used as predictors for the success of fertility treatments. Further studies are needed to assess the impact of transforming a dysbiotic flora into a eubiotic environment on the success of fertility treatments. MDPI 2023-05-25 /pmc/articles/PMC10304662/ /pubmed/37374032 http://dx.doi.org/10.3390/life13061251 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Findeklee, Sebastian
Urban, Lena
Sima, Romina-Marina
Baus, Simona Lucia
Halfmann, Alexander
Wagenpfeil, Gudrun
Solomayer, Erich-Franz
Haj Hamoud, Bashar
The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women
title The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women
title_full The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women
title_fullStr The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women
title_full_unstemmed The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women
title_short The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women
title_sort impact of the microbiological vaginal swab on the reproductive outcome in infertile women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304662/
https://www.ncbi.nlm.nih.gov/pubmed/37374032
http://dx.doi.org/10.3390/life13061251
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