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Detection of Asymptomatic Mpox Carriers among High-Ri Men Who Have Sex with Men: A Prospective Analysis

Mpox is traditionally considered a zoonotic disease with endemic circulation in Africa, but the 2022–2023 outbreak reached an unprecedented high number of cases in non-endemic countries, so that it was declared a public health emergency of international concern. The reasons for this extensive global...

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Autores principales: Rossotti, Roberto, Calzavara, Daniele, Cernuschi, Massimo, D’Amico, Federico, De Bona, Anna, Repossi, Roberto, Moschese, Davide, Bossolasco, Simona, Tavelli, Alessandro, Muccini, Camilla, Mulé, Giovanni, d’Arminio Monforte, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304703/
https://www.ncbi.nlm.nih.gov/pubmed/37375488
http://dx.doi.org/10.3390/pathogens12060798
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author Rossotti, Roberto
Calzavara, Daniele
Cernuschi, Massimo
D’Amico, Federico
De Bona, Anna
Repossi, Roberto
Moschese, Davide
Bossolasco, Simona
Tavelli, Alessandro
Muccini, Camilla
Mulé, Giovanni
d’Arminio Monforte, Antonella
author_facet Rossotti, Roberto
Calzavara, Daniele
Cernuschi, Massimo
D’Amico, Federico
De Bona, Anna
Repossi, Roberto
Moschese, Davide
Bossolasco, Simona
Tavelli, Alessandro
Muccini, Camilla
Mulé, Giovanni
d’Arminio Monforte, Antonella
author_sort Rossotti, Roberto
collection PubMed
description Mpox is traditionally considered a zoonotic disease with endemic circulation in Africa, but the 2022–2023 outbreak reached an unprecedented high number of cases in non-endemic countries, so that it was declared a public health emergency of international concern. The reasons for this extensive global spread, characterized by sexual transmission amongst men who have sex with men (MSM), have not been fully clarified. The existence of asymptomatic carriers with viable viral shedding might be an explanation and is under-debated after retrospective studies suggested that infection without symptoms might have a prevalence of 6.5%. We aimed to prospectively assess the presence of mpox infection in asymptomatic high-risk MSM using HIV pre-exposure prophylaxis and living with HIV. We selected individuals with no signs of active infection nor suggestive symptoms in the previous 21 days. Eligible individuals collected oral and anal swabs to undergo point-of-care testing for mpox and completed a 21-days follow-up. Seventy-two individuals were enrolled, and none tested positive for mpox infection nor developed symptoms during follow-up. We selected a high-risk population with a significant history of sexual exposure, but we failed to detect any asymptomatic infection. This observation might have important consequences in terms of contact management and epidemic control.
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spelling pubmed-103047032023-06-29 Detection of Asymptomatic Mpox Carriers among High-Ri Men Who Have Sex with Men: A Prospective Analysis Rossotti, Roberto Calzavara, Daniele Cernuschi, Massimo D’Amico, Federico De Bona, Anna Repossi, Roberto Moschese, Davide Bossolasco, Simona Tavelli, Alessandro Muccini, Camilla Mulé, Giovanni d’Arminio Monforte, Antonella Pathogens Brief Report Mpox is traditionally considered a zoonotic disease with endemic circulation in Africa, but the 2022–2023 outbreak reached an unprecedented high number of cases in non-endemic countries, so that it was declared a public health emergency of international concern. The reasons for this extensive global spread, characterized by sexual transmission amongst men who have sex with men (MSM), have not been fully clarified. The existence of asymptomatic carriers with viable viral shedding might be an explanation and is under-debated after retrospective studies suggested that infection without symptoms might have a prevalence of 6.5%. We aimed to prospectively assess the presence of mpox infection in asymptomatic high-risk MSM using HIV pre-exposure prophylaxis and living with HIV. We selected individuals with no signs of active infection nor suggestive symptoms in the previous 21 days. Eligible individuals collected oral and anal swabs to undergo point-of-care testing for mpox and completed a 21-days follow-up. Seventy-two individuals were enrolled, and none tested positive for mpox infection nor developed symptoms during follow-up. We selected a high-risk population with a significant history of sexual exposure, but we failed to detect any asymptomatic infection. This observation might have important consequences in terms of contact management and epidemic control. MDPI 2023-06-03 /pmc/articles/PMC10304703/ /pubmed/37375488 http://dx.doi.org/10.3390/pathogens12060798 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Rossotti, Roberto
Calzavara, Daniele
Cernuschi, Massimo
D’Amico, Federico
De Bona, Anna
Repossi, Roberto
Moschese, Davide
Bossolasco, Simona
Tavelli, Alessandro
Muccini, Camilla
Mulé, Giovanni
d’Arminio Monforte, Antonella
Detection of Asymptomatic Mpox Carriers among High-Ri Men Who Have Sex with Men: A Prospective Analysis
title Detection of Asymptomatic Mpox Carriers among High-Ri Men Who Have Sex with Men: A Prospective Analysis
title_full Detection of Asymptomatic Mpox Carriers among High-Ri Men Who Have Sex with Men: A Prospective Analysis
title_fullStr Detection of Asymptomatic Mpox Carriers among High-Ri Men Who Have Sex with Men: A Prospective Analysis
title_full_unstemmed Detection of Asymptomatic Mpox Carriers among High-Ri Men Who Have Sex with Men: A Prospective Analysis
title_short Detection of Asymptomatic Mpox Carriers among High-Ri Men Who Have Sex with Men: A Prospective Analysis
title_sort detection of asymptomatic mpox carriers among high-ri men who have sex with men: a prospective analysis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304703/
https://www.ncbi.nlm.nih.gov/pubmed/37375488
http://dx.doi.org/10.3390/pathogens12060798
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