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Replication DNA polymerases, genome instability and cancer therapies
It has been over a decade since the initial identification of exonuclease domain mutations in the genes encoding the catalytic subunits of replication DNA polymerases ϵ and δ (POLE and POLD1) in tumors from highly mutated endometrial and colorectal cancers. Interest in studying POLE and POLD1 has in...
Autores principales: | Strauss, Juliet D, Pursell, Zachary F |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304742/ https://www.ncbi.nlm.nih.gov/pubmed/37388540 http://dx.doi.org/10.1093/narcan/zcad033 |
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