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Scaffold Chemical Model Based on Collagen—Methyl Methacrylate Graft Copolymers

Polymerization of methyl methacrylate (MMA) in aqueous collagen (Col) dispersion was studied in the presence of tributylborane (TBB) and p-quinone: 2,5-di-tert-butyl-p-benzoquinone (2,5-DTBQ), p-benzoquinone (BQ), duroquinone (DQ), and p-naphthoquinone (NQ). It was found that this system leads to th...

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Autores principales: Kuznetsova, Yulia L., Gushchina, Ksenya S., Lobanova, Karina S., Chasova, Victoria O., Egorikhina, Marfa N., Grigoreva, Alexandra O., Malysheva, Yulia B., Kuzmina, Daria A., Farafontova, Ekaterina A., Linkova, Daria D., Rubtsova, Yulia P., Semenycheva, Luydmila L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304805/
https://www.ncbi.nlm.nih.gov/pubmed/37376264
http://dx.doi.org/10.3390/polym15122618
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author Kuznetsova, Yulia L.
Gushchina, Ksenya S.
Lobanova, Karina S.
Chasova, Victoria O.
Egorikhina, Marfa N.
Grigoreva, Alexandra O.
Malysheva, Yulia B.
Kuzmina, Daria A.
Farafontova, Ekaterina A.
Linkova, Daria D.
Rubtsova, Yulia P.
Semenycheva, Luydmila L.
author_facet Kuznetsova, Yulia L.
Gushchina, Ksenya S.
Lobanova, Karina S.
Chasova, Victoria O.
Egorikhina, Marfa N.
Grigoreva, Alexandra O.
Malysheva, Yulia B.
Kuzmina, Daria A.
Farafontova, Ekaterina A.
Linkova, Daria D.
Rubtsova, Yulia P.
Semenycheva, Luydmila L.
author_sort Kuznetsova, Yulia L.
collection PubMed
description Polymerization of methyl methacrylate (MMA) in aqueous collagen (Col) dispersion was studied in the presence of tributylborane (TBB) and p-quinone: 2,5-di-tert-butyl-p-benzoquinone (2,5-DTBQ), p-benzoquinone (BQ), duroquinone (DQ), and p-naphthoquinone (NQ). It was found that this system leads to the formation of a grafted cross-linked copolymer. The inhibitory effect of p-quinone determines the amount of unreacted monomer, homopolymer, and percentage of grafted poly(methyl methacrylate) (PMMA). The synthesis combines two approaches to form a grafted copolymer with a cross-linked structure—“grafting to” and “grafting from”. The resulting products exhibit biodegradation under the action of enzymes, do not have toxicity, and demonstrate a stimulating effect on cell growth. At the same time, the denaturation of collagen occurring at elevated temperatures does not impair the characteristics of copolymers. These results allow us to present the research as a scaffold chemical model. Comparison of the properties of the obtained copolymers helps to determine the optimal method for the synthesis of scaffold precursors—synthesis of a collagen and poly(methyl methacrylate) copolymer at 60 °C in a 1% acetic acid dispersion of fish collagen with a mass ratio of the components collagen:MMA:TBB:2,5-DTBQ equal to 1:1:0.015:0.25.
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spelling pubmed-103048052023-06-29 Scaffold Chemical Model Based on Collagen—Methyl Methacrylate Graft Copolymers Kuznetsova, Yulia L. Gushchina, Ksenya S. Lobanova, Karina S. Chasova, Victoria O. Egorikhina, Marfa N. Grigoreva, Alexandra O. Malysheva, Yulia B. Kuzmina, Daria A. Farafontova, Ekaterina A. Linkova, Daria D. Rubtsova, Yulia P. Semenycheva, Luydmila L. Polymers (Basel) Article Polymerization of methyl methacrylate (MMA) in aqueous collagen (Col) dispersion was studied in the presence of tributylborane (TBB) and p-quinone: 2,5-di-tert-butyl-p-benzoquinone (2,5-DTBQ), p-benzoquinone (BQ), duroquinone (DQ), and p-naphthoquinone (NQ). It was found that this system leads to the formation of a grafted cross-linked copolymer. The inhibitory effect of p-quinone determines the amount of unreacted monomer, homopolymer, and percentage of grafted poly(methyl methacrylate) (PMMA). The synthesis combines two approaches to form a grafted copolymer with a cross-linked structure—“grafting to” and “grafting from”. The resulting products exhibit biodegradation under the action of enzymes, do not have toxicity, and demonstrate a stimulating effect on cell growth. At the same time, the denaturation of collagen occurring at elevated temperatures does not impair the characteristics of copolymers. These results allow us to present the research as a scaffold chemical model. Comparison of the properties of the obtained copolymers helps to determine the optimal method for the synthesis of scaffold precursors—synthesis of a collagen and poly(methyl methacrylate) copolymer at 60 °C in a 1% acetic acid dispersion of fish collagen with a mass ratio of the components collagen:MMA:TBB:2,5-DTBQ equal to 1:1:0.015:0.25. MDPI 2023-06-08 /pmc/articles/PMC10304805/ /pubmed/37376264 http://dx.doi.org/10.3390/polym15122618 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kuznetsova, Yulia L.
Gushchina, Ksenya S.
Lobanova, Karina S.
Chasova, Victoria O.
Egorikhina, Marfa N.
Grigoreva, Alexandra O.
Malysheva, Yulia B.
Kuzmina, Daria A.
Farafontova, Ekaterina A.
Linkova, Daria D.
Rubtsova, Yulia P.
Semenycheva, Luydmila L.
Scaffold Chemical Model Based on Collagen—Methyl Methacrylate Graft Copolymers
title Scaffold Chemical Model Based on Collagen—Methyl Methacrylate Graft Copolymers
title_full Scaffold Chemical Model Based on Collagen—Methyl Methacrylate Graft Copolymers
title_fullStr Scaffold Chemical Model Based on Collagen—Methyl Methacrylate Graft Copolymers
title_full_unstemmed Scaffold Chemical Model Based on Collagen—Methyl Methacrylate Graft Copolymers
title_short Scaffold Chemical Model Based on Collagen—Methyl Methacrylate Graft Copolymers
title_sort scaffold chemical model based on collagen—methyl methacrylate graft copolymers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304805/
https://www.ncbi.nlm.nih.gov/pubmed/37376264
http://dx.doi.org/10.3390/polym15122618
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