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Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients
Objective To study a sample of rheumatoid arthritis (RA) patients for their gynecological/obstetric history and compare them to controls to determine their influences on number of pregnancies, menarche, menopause and reproductive years following RA onset. Methods This is a cross-sectional study of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304980/ https://www.ncbi.nlm.nih.gov/pubmed/34077986 http://dx.doi.org/10.1055/s-0041-1729149 |
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author | Cavalcante, Anauá Fernanda dos Santos Martin, Patrícia Skare, Thelma Larocca |
author_facet | Cavalcante, Anauá Fernanda dos Santos Martin, Patrícia Skare, Thelma Larocca |
author_sort | Cavalcante, Anauá Fernanda dos Santos |
collection | PubMed |
description | Objective To study a sample of rheumatoid arthritis (RA) patients for their gynecological/obstetric history and compare them to controls to determine their influences on number of pregnancies, menarche, menopause and reproductive years following RA onset. Methods This is a cross-sectional study of 122 RA patients and 126 controls. Patients and controls were questioned about age of menarche, age of menopause, number of pregnancies and abortions. Reproductive years were calculated as the difference between age at menopause and age at menarche. For comparison, we used the Mann-Whitney, unpaired t , chi-squared, and Spearman tests. The adopted significance was 5%. Results In the RA patients with disease beginning in the postmenopausal years, the period of reproductive years (age at menopause – age of menarche) showed a positive correlation with age at disease onset (rho = 0.46; 95% confidence interval [CI] = 0.20–0.55 with p = 0.0008). The number of pregnancies was higher in patients with postmenopausal disease onset when compared with those with premenopausal disease onset (median of 3 with interquartile range [IQR] = 2–4 versus median of 2 with IQR = 1–3; p = 0.009), and RA patients had more pregnancies than controls ( p = 0.0002). Conclusion The present study shows that, in our population, the duration of reproductive years and the number of pregnancies are linked to the onset of RA. |
format | Online Article Text |
id | pubmed-10304980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Thieme Revinter Publicações Ltda. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103049802023-07-27 Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients Cavalcante, Anauá Fernanda dos Santos Martin, Patrícia Skare, Thelma Larocca Rev Bras Ginecol Obstet Objective To study a sample of rheumatoid arthritis (RA) patients for their gynecological/obstetric history and compare them to controls to determine their influences on number of pregnancies, menarche, menopause and reproductive years following RA onset. Methods This is a cross-sectional study of 122 RA patients and 126 controls. Patients and controls were questioned about age of menarche, age of menopause, number of pregnancies and abortions. Reproductive years were calculated as the difference between age at menopause and age at menarche. For comparison, we used the Mann-Whitney, unpaired t , chi-squared, and Spearman tests. The adopted significance was 5%. Results In the RA patients with disease beginning in the postmenopausal years, the period of reproductive years (age at menopause – age of menarche) showed a positive correlation with age at disease onset (rho = 0.46; 95% confidence interval [CI] = 0.20–0.55 with p = 0.0008). The number of pregnancies was higher in patients with postmenopausal disease onset when compared with those with premenopausal disease onset (median of 3 with interquartile range [IQR] = 2–4 versus median of 2 with IQR = 1–3; p = 0.009), and RA patients had more pregnancies than controls ( p = 0.0002). Conclusion The present study shows that, in our population, the duration of reproductive years and the number of pregnancies are linked to the onset of RA. Thieme Revinter Publicações Ltda. 2021-06-02 /pmc/articles/PMC10304980/ /pubmed/34077986 http://dx.doi.org/10.1055/s-0041-1729149 Text en Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cavalcante, Anauá Fernanda dos Santos Martin, Patrícia Skare, Thelma Larocca Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients |
title | Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients |
title_full | Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients |
title_fullStr | Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients |
title_full_unstemmed | Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients |
title_short | Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients |
title_sort | gynecological/obstetric background and rheumatoid arthritis: a cross-sectional study in brazilian patients |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304980/ https://www.ncbi.nlm.nih.gov/pubmed/34077986 http://dx.doi.org/10.1055/s-0041-1729149 |
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