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Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients

Objective  To study a sample of rheumatoid arthritis (RA) patients for their gynecological/obstetric history and compare them to controls to determine their influences on number of pregnancies, menarche, menopause and reproductive years following RA onset. Methods  This is a cross-sectional study of...

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Autores principales: Cavalcante, Anauá Fernanda dos Santos, Martin, Patrícia, Skare, Thelma Larocca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda. 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304980/
https://www.ncbi.nlm.nih.gov/pubmed/34077986
http://dx.doi.org/10.1055/s-0041-1729149
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author Cavalcante, Anauá Fernanda dos Santos
Martin, Patrícia
Skare, Thelma Larocca
author_facet Cavalcante, Anauá Fernanda dos Santos
Martin, Patrícia
Skare, Thelma Larocca
author_sort Cavalcante, Anauá Fernanda dos Santos
collection PubMed
description Objective  To study a sample of rheumatoid arthritis (RA) patients for their gynecological/obstetric history and compare them to controls to determine their influences on number of pregnancies, menarche, menopause and reproductive years following RA onset. Methods  This is a cross-sectional study of 122 RA patients and 126 controls. Patients and controls were questioned about age of menarche, age of menopause, number of pregnancies and abortions. Reproductive years were calculated as the difference between age at menopause and age at menarche. For comparison, we used the Mann-Whitney, unpaired t , chi-squared, and Spearman tests. The adopted significance was 5%. Results  In the RA patients with disease beginning in the postmenopausal years, the period of reproductive years (age at menopause – age of menarche) showed a positive correlation with age at disease onset (rho = 0.46; 95% confidence interval [CI] = 0.20–0.55 with p  = 0.0008). The number of pregnancies was higher in patients with postmenopausal disease onset when compared with those with premenopausal disease onset (median of 3 with interquartile range [IQR] = 2–4 versus median of 2 with IQR = 1–3; p  = 0.009), and RA patients had more pregnancies than controls ( p  = 0.0002). Conclusion  The present study shows that, in our population, the duration of reproductive years and the number of pregnancies are linked to the onset of RA.
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spelling pubmed-103049802023-07-27 Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients Cavalcante, Anauá Fernanda dos Santos Martin, Patrícia Skare, Thelma Larocca Rev Bras Ginecol Obstet Objective  To study a sample of rheumatoid arthritis (RA) patients for their gynecological/obstetric history and compare them to controls to determine their influences on number of pregnancies, menarche, menopause and reproductive years following RA onset. Methods  This is a cross-sectional study of 122 RA patients and 126 controls. Patients and controls were questioned about age of menarche, age of menopause, number of pregnancies and abortions. Reproductive years were calculated as the difference between age at menopause and age at menarche. For comparison, we used the Mann-Whitney, unpaired t , chi-squared, and Spearman tests. The adopted significance was 5%. Results  In the RA patients with disease beginning in the postmenopausal years, the period of reproductive years (age at menopause – age of menarche) showed a positive correlation with age at disease onset (rho = 0.46; 95% confidence interval [CI] = 0.20–0.55 with p  = 0.0008). The number of pregnancies was higher in patients with postmenopausal disease onset when compared with those with premenopausal disease onset (median of 3 with interquartile range [IQR] = 2–4 versus median of 2 with IQR = 1–3; p  = 0.009), and RA patients had more pregnancies than controls ( p  = 0.0002). Conclusion  The present study shows that, in our population, the duration of reproductive years and the number of pregnancies are linked to the onset of RA. Thieme Revinter Publicações Ltda. 2021-06-02 /pmc/articles/PMC10304980/ /pubmed/34077986 http://dx.doi.org/10.1055/s-0041-1729149 Text en Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cavalcante, Anauá Fernanda dos Santos
Martin, Patrícia
Skare, Thelma Larocca
Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients
title Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients
title_full Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients
title_fullStr Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients
title_full_unstemmed Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients
title_short Gynecological/Obstetric Background and Rheumatoid Arthritis: A Cross-sectional Study in Brazilian Patients
title_sort gynecological/obstetric background and rheumatoid arthritis: a cross-sectional study in brazilian patients
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304980/
https://www.ncbi.nlm.nih.gov/pubmed/34077986
http://dx.doi.org/10.1055/s-0041-1729149
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