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Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity

BACKGROUND: Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism. Aberrant functioning of the endocannabinoid system has been observed in extreme weight conditions (EWCs), suggesting it may influence pathophysio...

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Autores principales: Baenas, Isabel, Miranda-Olivos, Romina, Granero, Roser, Solé-Morata, Neus, Sánchez, Isabel, Pastor, Antoni, del Pino-Gutiérrez, Amparo, Codina, Ester, Tinahones, Francisco J., Fernández-Formoso, José A., Vilarrasa, Núria, Guerrero-Pérez, Fernando, Lopez-Urdiales, Rafael, Virgili, Núria, Soriano-Mas, Carles, Jiménez-Murcia, Susana, de la Torre, Rafael, Fernández-Aranda, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305007/
https://www.ncbi.nlm.nih.gov/pubmed/37254556
http://dx.doi.org/10.1192/j.eurpsy.2023.2411
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author Baenas, Isabel
Miranda-Olivos, Romina
Granero, Roser
Solé-Morata, Neus
Sánchez, Isabel
Pastor, Antoni
del Pino-Gutiérrez, Amparo
Codina, Ester
Tinahones, Francisco J.
Fernández-Formoso, José A.
Vilarrasa, Núria
Guerrero-Pérez, Fernando
Lopez-Urdiales, Rafael
Virgili, Núria
Soriano-Mas, Carles
Jiménez-Murcia, Susana
de la Torre, Rafael
Fernández-Aranda, Fernando
author_facet Baenas, Isabel
Miranda-Olivos, Romina
Granero, Roser
Solé-Morata, Neus
Sánchez, Isabel
Pastor, Antoni
del Pino-Gutiérrez, Amparo
Codina, Ester
Tinahones, Francisco J.
Fernández-Formoso, José A.
Vilarrasa, Núria
Guerrero-Pérez, Fernando
Lopez-Urdiales, Rafael
Virgili, Núria
Soriano-Mas, Carles
Jiménez-Murcia, Susana
de la Torre, Rafael
Fernández-Aranda, Fernando
author_sort Baenas, Isabel
collection PubMed
description BACKGROUND: Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism. Aberrant functioning of the endocannabinoid system has been observed in extreme weight conditions (EWCs), suggesting it may influence pathophysiology. Then, we aimed to analyze fasting AEA and 2-AG plasma concentrations among individuals with EWC (i.e., anorexia nervosa [AN] and obesity with and without eating disorders [EDs]) compared with healthy controls (HCs), and its association with clinical variables and body mass index (BMI). METHODS: The sample included 113 adult women. Fifty-seven belonged to the obesity group, 37 without EDs (OB-ED) and 20 with ED (OB+ED classified within the binge spectrum disorders), 27 individuals from the AN group, and 29 from the HC group. Peripheral blood samples, several clinical variables, and BMI were evaluated. RESULTS: Unlike 2-AG, AEA concentrations showed significant differences between groups (p < 0.001). Increased AEA was observed in the OB-ED and OB+ED compared with both HC and AN group, respectively. Likewise, AEA was differentially associated with emotional dysregulation, general psychopathology, food addiction, and BMI in all clinical groups. CONCLUSIONS: These results support the interaction between biological and clinical factors contributing to delineating vulnerability pathways in EWC that could help fit personalized therapeutic approaches.
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spelling pubmed-103050072023-06-29 Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity Baenas, Isabel Miranda-Olivos, Romina Granero, Roser Solé-Morata, Neus Sánchez, Isabel Pastor, Antoni del Pino-Gutiérrez, Amparo Codina, Ester Tinahones, Francisco J. Fernández-Formoso, José A. Vilarrasa, Núria Guerrero-Pérez, Fernando Lopez-Urdiales, Rafael Virgili, Núria Soriano-Mas, Carles Jiménez-Murcia, Susana de la Torre, Rafael Fernández-Aranda, Fernando Eur Psychiatry Research Article BACKGROUND: Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism. Aberrant functioning of the endocannabinoid system has been observed in extreme weight conditions (EWCs), suggesting it may influence pathophysiology. Then, we aimed to analyze fasting AEA and 2-AG plasma concentrations among individuals with EWC (i.e., anorexia nervosa [AN] and obesity with and without eating disorders [EDs]) compared with healthy controls (HCs), and its association with clinical variables and body mass index (BMI). METHODS: The sample included 113 adult women. Fifty-seven belonged to the obesity group, 37 without EDs (OB-ED) and 20 with ED (OB+ED classified within the binge spectrum disorders), 27 individuals from the AN group, and 29 from the HC group. Peripheral blood samples, several clinical variables, and BMI were evaluated. RESULTS: Unlike 2-AG, AEA concentrations showed significant differences between groups (p < 0.001). Increased AEA was observed in the OB-ED and OB+ED compared with both HC and AN group, respectively. Likewise, AEA was differentially associated with emotional dysregulation, general psychopathology, food addiction, and BMI in all clinical groups. CONCLUSIONS: These results support the interaction between biological and clinical factors contributing to delineating vulnerability pathways in EWC that could help fit personalized therapeutic approaches. Cambridge University Press 2023-05-31 /pmc/articles/PMC10305007/ /pubmed/37254556 http://dx.doi.org/10.1192/j.eurpsy.2023.2411 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Research Article
Baenas, Isabel
Miranda-Olivos, Romina
Granero, Roser
Solé-Morata, Neus
Sánchez, Isabel
Pastor, Antoni
del Pino-Gutiérrez, Amparo
Codina, Ester
Tinahones, Francisco J.
Fernández-Formoso, José A.
Vilarrasa, Núria
Guerrero-Pérez, Fernando
Lopez-Urdiales, Rafael
Virgili, Núria
Soriano-Mas, Carles
Jiménez-Murcia, Susana
de la Torre, Rafael
Fernández-Aranda, Fernando
Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity
title Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity
title_full Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity
title_fullStr Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity
title_full_unstemmed Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity
title_short Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity
title_sort association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305007/
https://www.ncbi.nlm.nih.gov/pubmed/37254556
http://dx.doi.org/10.1192/j.eurpsy.2023.2411
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