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Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients
Neuroinflammation is critical in developing and progressing neurological diseases. The underlying pro-inflammatory cytokine expression combined with additional mechanisms in the neuropathology, such as oxidative stress, brain–blood barrier damage, and endothelial dysfunction, could contribute to the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305010/ https://www.ncbi.nlm.nih.gov/pubmed/37368708 http://dx.doi.org/10.3390/tropicalmed8060290 |
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author | Méndez-García, Lucía Angélica Solleiro-Villavicencio, Helena Guartazaca-Guerrero, Sebastián Rodríguez-Morales, Jahir Carrillo-Ruiz, José Damián |
author_facet | Méndez-García, Lucía Angélica Solleiro-Villavicencio, Helena Guartazaca-Guerrero, Sebastián Rodríguez-Morales, Jahir Carrillo-Ruiz, José Damián |
author_sort | Méndez-García, Lucía Angélica |
collection | PubMed |
description | Neuroinflammation is critical in developing and progressing neurological diseases. The underlying pro-inflammatory cytokine expression combined with additional mechanisms in the neuropathology, such as oxidative stress, brain–blood barrier damage, and endothelial dysfunction, could contribute to the susceptibility to developing severe COVID-19. The physiopathology of SARS-CoV-2 and other human coronaviruses (H-CoVs) has not been completely understood; however, they have all been linked to a disproportionated response of the immune system, particularly an exacerbated cytokine production and the dysregulation of total cell counts. In this article, based on the compilation of studies reported by our working group regarding COVID-19 and neurological diseases, we propose that the inflammation observed in the central nervous system, through a CSF analysis, could be conditioned by neurological disease(s) and enhanced by COVID-19. Therefore, it is necessary to determine the cytokine profile in different neurological disorders to propose adequate treatments and avoid severe forms of the disease in these patients. |
format | Online Article Text |
id | pubmed-10305010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103050102023-06-29 Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients Méndez-García, Lucía Angélica Solleiro-Villavicencio, Helena Guartazaca-Guerrero, Sebastián Rodríguez-Morales, Jahir Carrillo-Ruiz, José Damián Trop Med Infect Dis Opinion Neuroinflammation is critical in developing and progressing neurological diseases. The underlying pro-inflammatory cytokine expression combined with additional mechanisms in the neuropathology, such as oxidative stress, brain–blood barrier damage, and endothelial dysfunction, could contribute to the susceptibility to developing severe COVID-19. The physiopathology of SARS-CoV-2 and other human coronaviruses (H-CoVs) has not been completely understood; however, they have all been linked to a disproportionated response of the immune system, particularly an exacerbated cytokine production and the dysregulation of total cell counts. In this article, based on the compilation of studies reported by our working group regarding COVID-19 and neurological diseases, we propose that the inflammation observed in the central nervous system, through a CSF analysis, could be conditioned by neurological disease(s) and enhanced by COVID-19. Therefore, it is necessary to determine the cytokine profile in different neurological disorders to propose adequate treatments and avoid severe forms of the disease in these patients. MDPI 2023-05-25 /pmc/articles/PMC10305010/ /pubmed/37368708 http://dx.doi.org/10.3390/tropicalmed8060290 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Opinion Méndez-García, Lucía Angélica Solleiro-Villavicencio, Helena Guartazaca-Guerrero, Sebastián Rodríguez-Morales, Jahir Carrillo-Ruiz, José Damián Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients |
title | Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients |
title_full | Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients |
title_fullStr | Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients |
title_full_unstemmed | Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients |
title_short | Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients |
title_sort | neurological diseases define the cytokine profile in cfs during sars-cov-2 infection in highly ill patients |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305010/ https://www.ncbi.nlm.nih.gov/pubmed/37368708 http://dx.doi.org/10.3390/tropicalmed8060290 |
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