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Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients

Neuroinflammation is critical in developing and progressing neurological diseases. The underlying pro-inflammatory cytokine expression combined with additional mechanisms in the neuropathology, such as oxidative stress, brain–blood barrier damage, and endothelial dysfunction, could contribute to the...

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Autores principales: Méndez-García, Lucía Angélica, Solleiro-Villavicencio, Helena, Guartazaca-Guerrero, Sebastián, Rodríguez-Morales, Jahir, Carrillo-Ruiz, José Damián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305010/
https://www.ncbi.nlm.nih.gov/pubmed/37368708
http://dx.doi.org/10.3390/tropicalmed8060290
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author Méndez-García, Lucía Angélica
Solleiro-Villavicencio, Helena
Guartazaca-Guerrero, Sebastián
Rodríguez-Morales, Jahir
Carrillo-Ruiz, José Damián
author_facet Méndez-García, Lucía Angélica
Solleiro-Villavicencio, Helena
Guartazaca-Guerrero, Sebastián
Rodríguez-Morales, Jahir
Carrillo-Ruiz, José Damián
author_sort Méndez-García, Lucía Angélica
collection PubMed
description Neuroinflammation is critical in developing and progressing neurological diseases. The underlying pro-inflammatory cytokine expression combined with additional mechanisms in the neuropathology, such as oxidative stress, brain–blood barrier damage, and endothelial dysfunction, could contribute to the susceptibility to developing severe COVID-19. The physiopathology of SARS-CoV-2 and other human coronaviruses (H-CoVs) has not been completely understood; however, they have all been linked to a disproportionated response of the immune system, particularly an exacerbated cytokine production and the dysregulation of total cell counts. In this article, based on the compilation of studies reported by our working group regarding COVID-19 and neurological diseases, we propose that the inflammation observed in the central nervous system, through a CSF analysis, could be conditioned by neurological disease(s) and enhanced by COVID-19. Therefore, it is necessary to determine the cytokine profile in different neurological disorders to propose adequate treatments and avoid severe forms of the disease in these patients.
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spelling pubmed-103050102023-06-29 Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients Méndez-García, Lucía Angélica Solleiro-Villavicencio, Helena Guartazaca-Guerrero, Sebastián Rodríguez-Morales, Jahir Carrillo-Ruiz, José Damián Trop Med Infect Dis Opinion Neuroinflammation is critical in developing and progressing neurological diseases. The underlying pro-inflammatory cytokine expression combined with additional mechanisms in the neuropathology, such as oxidative stress, brain–blood barrier damage, and endothelial dysfunction, could contribute to the susceptibility to developing severe COVID-19. The physiopathology of SARS-CoV-2 and other human coronaviruses (H-CoVs) has not been completely understood; however, they have all been linked to a disproportionated response of the immune system, particularly an exacerbated cytokine production and the dysregulation of total cell counts. In this article, based on the compilation of studies reported by our working group regarding COVID-19 and neurological diseases, we propose that the inflammation observed in the central nervous system, through a CSF analysis, could be conditioned by neurological disease(s) and enhanced by COVID-19. Therefore, it is necessary to determine the cytokine profile in different neurological disorders to propose adequate treatments and avoid severe forms of the disease in these patients. MDPI 2023-05-25 /pmc/articles/PMC10305010/ /pubmed/37368708 http://dx.doi.org/10.3390/tropicalmed8060290 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Méndez-García, Lucía Angélica
Solleiro-Villavicencio, Helena
Guartazaca-Guerrero, Sebastián
Rodríguez-Morales, Jahir
Carrillo-Ruiz, José Damián
Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients
title Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients
title_full Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients
title_fullStr Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients
title_full_unstemmed Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients
title_short Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients
title_sort neurological diseases define the cytokine profile in cfs during sars-cov-2 infection in highly ill patients
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305010/
https://www.ncbi.nlm.nih.gov/pubmed/37368708
http://dx.doi.org/10.3390/tropicalmed8060290
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