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Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient

Background and Objectives: Increasing attention is being paid to the coagulation disorders associated with SARS-CoV-2 infection. Bleeding accounts for 3–6% of COVID-19 patient deaths, and is often a forgotten part of the disease. The bleeding risk is enhanced by several factors, including spontaneou...

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Autores principales: Minici, Roberto, Fontana, Federico, Venturini, Massimo, Guzzardi, Giuseppe, Siciliano, Agostino, Piacentino, Filippo, Serra, Raffaele, Coppola, Andrea, Guerriero, Pasquale, Apollonio, Biagio, Santoro, Rita, Team, MGJR Research, Brunese, Luca, Laganà, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305036/
https://www.ncbi.nlm.nih.gov/pubmed/37374266
http://dx.doi.org/10.3390/medicina59061062
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author Minici, Roberto
Fontana, Federico
Venturini, Massimo
Guzzardi, Giuseppe
Siciliano, Agostino
Piacentino, Filippo
Serra, Raffaele
Coppola, Andrea
Guerriero, Pasquale
Apollonio, Biagio
Santoro, Rita
Team, MGJR Research
Brunese, Luca
Laganà, Domenico
author_facet Minici, Roberto
Fontana, Federico
Venturini, Massimo
Guzzardi, Giuseppe
Siciliano, Agostino
Piacentino, Filippo
Serra, Raffaele
Coppola, Andrea
Guerriero, Pasquale
Apollonio, Biagio
Santoro, Rita
Team, MGJR Research
Brunese, Luca
Laganà, Domenico
author_sort Minici, Roberto
collection PubMed
description Background and Objectives: Increasing attention is being paid to the coagulation disorders associated with SARS-CoV-2 infection. Bleeding accounts for 3–6% of COVID-19 patient deaths, and is often a forgotten part of the disease. The bleeding risk is enhanced by several factors, including spontaneous heparin-induced thrombocytopenia, thrombocytopenia, the hyperfibrinolytic state, the consumption of coagulation factors, and thromboprophylaxis with anticoagulants. This study aims to assess the efficacy and safety of TAE in the management of bleeding in COVID-19 patients. Materials and Methods: This multicenter retrospective study analyzes data from COVID-19 patients subjected to transcatheter arterial embolization for the management of bleeding from February 2020 to January 2023. Results: Transcatheter arterial embolization was performed in 73 COVID-19 patients for acute non-neurovascular bleeding during the study interval (February 2020–January 2023). Coagulopathy was observed in forty-four (60.3%) patients. The primary cause of bleeding was spontaneous soft tissue hematoma (63%). A 100% technical success rate was recorded; six cases of rebleeding resulted in a 91.8% clinical success rate. No cases of non-target embolization were observed. Complications were recorded in 13 (17.8%) patients. The efficacy and safety endpoints did not differ significantly between the coagulopathy and non-coagulopathy groups. Conclusions: Transcatheter Arterial Embolization (TAE) is an effective, safe and potentially life-saving option for the management of acute non-neurovascular bleeding in COVID-19 patients. This approach is effective and safe even in the subgroup of COVID-19 patients with coagulopathy.
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spelling pubmed-103050362023-06-29 Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient Minici, Roberto Fontana, Federico Venturini, Massimo Guzzardi, Giuseppe Siciliano, Agostino Piacentino, Filippo Serra, Raffaele Coppola, Andrea Guerriero, Pasquale Apollonio, Biagio Santoro, Rita Team, MGJR Research Brunese, Luca Laganà, Domenico Medicina (Kaunas) Article Background and Objectives: Increasing attention is being paid to the coagulation disorders associated with SARS-CoV-2 infection. Bleeding accounts for 3–6% of COVID-19 patient deaths, and is often a forgotten part of the disease. The bleeding risk is enhanced by several factors, including spontaneous heparin-induced thrombocytopenia, thrombocytopenia, the hyperfibrinolytic state, the consumption of coagulation factors, and thromboprophylaxis with anticoagulants. This study aims to assess the efficacy and safety of TAE in the management of bleeding in COVID-19 patients. Materials and Methods: This multicenter retrospective study analyzes data from COVID-19 patients subjected to transcatheter arterial embolization for the management of bleeding from February 2020 to January 2023. Results: Transcatheter arterial embolization was performed in 73 COVID-19 patients for acute non-neurovascular bleeding during the study interval (February 2020–January 2023). Coagulopathy was observed in forty-four (60.3%) patients. The primary cause of bleeding was spontaneous soft tissue hematoma (63%). A 100% technical success rate was recorded; six cases of rebleeding resulted in a 91.8% clinical success rate. No cases of non-target embolization were observed. Complications were recorded in 13 (17.8%) patients. The efficacy and safety endpoints did not differ significantly between the coagulopathy and non-coagulopathy groups. Conclusions: Transcatheter Arterial Embolization (TAE) is an effective, safe and potentially life-saving option for the management of acute non-neurovascular bleeding in COVID-19 patients. This approach is effective and safe even in the subgroup of COVID-19 patients with coagulopathy. MDPI 2023-06-01 /pmc/articles/PMC10305036/ /pubmed/37374266 http://dx.doi.org/10.3390/medicina59061062 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Minici, Roberto
Fontana, Federico
Venturini, Massimo
Guzzardi, Giuseppe
Siciliano, Agostino
Piacentino, Filippo
Serra, Raffaele
Coppola, Andrea
Guerriero, Pasquale
Apollonio, Biagio
Santoro, Rita
Team, MGJR Research
Brunese, Luca
Laganà, Domenico
Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient
title Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient
title_full Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient
title_fullStr Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient
title_full_unstemmed Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient
title_short Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient
title_sort transcatheter arterial embolization (tae) in the management of bleeding in the covid-19 patient
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305036/
https://www.ncbi.nlm.nih.gov/pubmed/37374266
http://dx.doi.org/10.3390/medicina59061062
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