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Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient
Background and Objectives: Increasing attention is being paid to the coagulation disorders associated with SARS-CoV-2 infection. Bleeding accounts for 3–6% of COVID-19 patient deaths, and is often a forgotten part of the disease. The bleeding risk is enhanced by several factors, including spontaneou...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305036/ https://www.ncbi.nlm.nih.gov/pubmed/37374266 http://dx.doi.org/10.3390/medicina59061062 |
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author | Minici, Roberto Fontana, Federico Venturini, Massimo Guzzardi, Giuseppe Siciliano, Agostino Piacentino, Filippo Serra, Raffaele Coppola, Andrea Guerriero, Pasquale Apollonio, Biagio Santoro, Rita Team, MGJR Research Brunese, Luca Laganà, Domenico |
author_facet | Minici, Roberto Fontana, Federico Venturini, Massimo Guzzardi, Giuseppe Siciliano, Agostino Piacentino, Filippo Serra, Raffaele Coppola, Andrea Guerriero, Pasquale Apollonio, Biagio Santoro, Rita Team, MGJR Research Brunese, Luca Laganà, Domenico |
author_sort | Minici, Roberto |
collection | PubMed |
description | Background and Objectives: Increasing attention is being paid to the coagulation disorders associated with SARS-CoV-2 infection. Bleeding accounts for 3–6% of COVID-19 patient deaths, and is often a forgotten part of the disease. The bleeding risk is enhanced by several factors, including spontaneous heparin-induced thrombocytopenia, thrombocytopenia, the hyperfibrinolytic state, the consumption of coagulation factors, and thromboprophylaxis with anticoagulants. This study aims to assess the efficacy and safety of TAE in the management of bleeding in COVID-19 patients. Materials and Methods: This multicenter retrospective study analyzes data from COVID-19 patients subjected to transcatheter arterial embolization for the management of bleeding from February 2020 to January 2023. Results: Transcatheter arterial embolization was performed in 73 COVID-19 patients for acute non-neurovascular bleeding during the study interval (February 2020–January 2023). Coagulopathy was observed in forty-four (60.3%) patients. The primary cause of bleeding was spontaneous soft tissue hematoma (63%). A 100% technical success rate was recorded; six cases of rebleeding resulted in a 91.8% clinical success rate. No cases of non-target embolization were observed. Complications were recorded in 13 (17.8%) patients. The efficacy and safety endpoints did not differ significantly between the coagulopathy and non-coagulopathy groups. Conclusions: Transcatheter Arterial Embolization (TAE) is an effective, safe and potentially life-saving option for the management of acute non-neurovascular bleeding in COVID-19 patients. This approach is effective and safe even in the subgroup of COVID-19 patients with coagulopathy. |
format | Online Article Text |
id | pubmed-10305036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103050362023-06-29 Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient Minici, Roberto Fontana, Federico Venturini, Massimo Guzzardi, Giuseppe Siciliano, Agostino Piacentino, Filippo Serra, Raffaele Coppola, Andrea Guerriero, Pasquale Apollonio, Biagio Santoro, Rita Team, MGJR Research Brunese, Luca Laganà, Domenico Medicina (Kaunas) Article Background and Objectives: Increasing attention is being paid to the coagulation disorders associated with SARS-CoV-2 infection. Bleeding accounts for 3–6% of COVID-19 patient deaths, and is often a forgotten part of the disease. The bleeding risk is enhanced by several factors, including spontaneous heparin-induced thrombocytopenia, thrombocytopenia, the hyperfibrinolytic state, the consumption of coagulation factors, and thromboprophylaxis with anticoagulants. This study aims to assess the efficacy and safety of TAE in the management of bleeding in COVID-19 patients. Materials and Methods: This multicenter retrospective study analyzes data from COVID-19 patients subjected to transcatheter arterial embolization for the management of bleeding from February 2020 to January 2023. Results: Transcatheter arterial embolization was performed in 73 COVID-19 patients for acute non-neurovascular bleeding during the study interval (February 2020–January 2023). Coagulopathy was observed in forty-four (60.3%) patients. The primary cause of bleeding was spontaneous soft tissue hematoma (63%). A 100% technical success rate was recorded; six cases of rebleeding resulted in a 91.8% clinical success rate. No cases of non-target embolization were observed. Complications were recorded in 13 (17.8%) patients. The efficacy and safety endpoints did not differ significantly between the coagulopathy and non-coagulopathy groups. Conclusions: Transcatheter Arterial Embolization (TAE) is an effective, safe and potentially life-saving option for the management of acute non-neurovascular bleeding in COVID-19 patients. This approach is effective and safe even in the subgroup of COVID-19 patients with coagulopathy. MDPI 2023-06-01 /pmc/articles/PMC10305036/ /pubmed/37374266 http://dx.doi.org/10.3390/medicina59061062 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Minici, Roberto Fontana, Federico Venturini, Massimo Guzzardi, Giuseppe Siciliano, Agostino Piacentino, Filippo Serra, Raffaele Coppola, Andrea Guerriero, Pasquale Apollonio, Biagio Santoro, Rita Team, MGJR Research Brunese, Luca Laganà, Domenico Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient |
title | Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient |
title_full | Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient |
title_fullStr | Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient |
title_full_unstemmed | Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient |
title_short | Transcatheter Arterial Embolization (TAE) in the Management of Bleeding in the COVID-19 Patient |
title_sort | transcatheter arterial embolization (tae) in the management of bleeding in the covid-19 patient |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305036/ https://www.ncbi.nlm.nih.gov/pubmed/37374266 http://dx.doi.org/10.3390/medicina59061062 |
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