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Production of Antioxidant Transfersomes by a Supercritical CO(2) Assisted Process for Transdermal Delivery Applications

Transfersomes are deformable vesicles that can transport drugs across difficult-to-permeate barriers in human tissues. In this work, nano-transfersomes were produced for the first time by a supercritical CO(2) assisted process. Operating at 100 bar and 40 °C, different amounts of phosphatidylcholine...

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Autores principales: Squittieri, Raffaella, Baldino, Lucia, Reverchon, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305085/
https://www.ncbi.nlm.nih.gov/pubmed/37368242
http://dx.doi.org/10.3390/nano13121812
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author Squittieri, Raffaella
Baldino, Lucia
Reverchon, Ernesto
author_facet Squittieri, Raffaella
Baldino, Lucia
Reverchon, Ernesto
author_sort Squittieri, Raffaella
collection PubMed
description Transfersomes are deformable vesicles that can transport drugs across difficult-to-permeate barriers in human tissues. In this work, nano-transfersomes were produced for the first time by a supercritical CO(2) assisted process. Operating at 100 bar and 40 °C, different amounts of phosphatidylcholine (2000 and 3000 mg), kinds of edge activators (Span(®) 80 and Tween(®) 80), and phosphatidylcholine to edge activator weight ratio (95:5, 90:10, 80:20) were tested. Formulations prepared using Span(®) 80 and phosphatidylcholine at an 80:20 weight ratio produced stable transfersomes (−30.4 ± 2.4 mV ζ-potential) that were characterized by a mean diameter of 138 ± 55 nm. A prolonged ascorbic acid release of up to 5 h was recorded when the largest amount of phosphatidylcholine (3000 mg) was used. Moreover, a 96% ascorbic acid encapsulation efficiency and a quasi-100% DPPH radical scavenging activity of transfersomes were measured after supercritical processing.
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spelling pubmed-103050852023-06-29 Production of Antioxidant Transfersomes by a Supercritical CO(2) Assisted Process for Transdermal Delivery Applications Squittieri, Raffaella Baldino, Lucia Reverchon, Ernesto Nanomaterials (Basel) Article Transfersomes are deformable vesicles that can transport drugs across difficult-to-permeate barriers in human tissues. In this work, nano-transfersomes were produced for the first time by a supercritical CO(2) assisted process. Operating at 100 bar and 40 °C, different amounts of phosphatidylcholine (2000 and 3000 mg), kinds of edge activators (Span(®) 80 and Tween(®) 80), and phosphatidylcholine to edge activator weight ratio (95:5, 90:10, 80:20) were tested. Formulations prepared using Span(®) 80 and phosphatidylcholine at an 80:20 weight ratio produced stable transfersomes (−30.4 ± 2.4 mV ζ-potential) that were characterized by a mean diameter of 138 ± 55 nm. A prolonged ascorbic acid release of up to 5 h was recorded when the largest amount of phosphatidylcholine (3000 mg) was used. Moreover, a 96% ascorbic acid encapsulation efficiency and a quasi-100% DPPH radical scavenging activity of transfersomes were measured after supercritical processing. MDPI 2023-06-06 /pmc/articles/PMC10305085/ /pubmed/37368242 http://dx.doi.org/10.3390/nano13121812 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Squittieri, Raffaella
Baldino, Lucia
Reverchon, Ernesto
Production of Antioxidant Transfersomes by a Supercritical CO(2) Assisted Process for Transdermal Delivery Applications
title Production of Antioxidant Transfersomes by a Supercritical CO(2) Assisted Process for Transdermal Delivery Applications
title_full Production of Antioxidant Transfersomes by a Supercritical CO(2) Assisted Process for Transdermal Delivery Applications
title_fullStr Production of Antioxidant Transfersomes by a Supercritical CO(2) Assisted Process for Transdermal Delivery Applications
title_full_unstemmed Production of Antioxidant Transfersomes by a Supercritical CO(2) Assisted Process for Transdermal Delivery Applications
title_short Production of Antioxidant Transfersomes by a Supercritical CO(2) Assisted Process for Transdermal Delivery Applications
title_sort production of antioxidant transfersomes by a supercritical co(2) assisted process for transdermal delivery applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305085/
https://www.ncbi.nlm.nih.gov/pubmed/37368242
http://dx.doi.org/10.3390/nano13121812
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