Cargando…
Compounded Effervescent Magnesium for Familial Hypomagnesemia: A Case Report
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive disorder affecting <1/1,000,000 people. It is caused by mutations in the CLDN16 (FHHNC Type 1) or CLDN19 (FHHNC Type 2) genes, which are located on Chromosomes 3q27 and 1p34.2, respectively. The...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305453/ https://www.ncbi.nlm.nih.gov/pubmed/37375733 http://dx.doi.org/10.3390/ph16060785 |
_version_ | 1785065737398779904 |
---|---|
author | Bennati, Giada Cirino, Mario Benericetti, Giulia Maximova, Natalia Zanier, Monica Pigato, Federico Parzianello, Anna Maestro, Alessandra Barbi, Egidio Zanon, Davide |
author_facet | Bennati, Giada Cirino, Mario Benericetti, Giulia Maximova, Natalia Zanier, Monica Pigato, Federico Parzianello, Anna Maestro, Alessandra Barbi, Egidio Zanon, Davide |
author_sort | Bennati, Giada |
collection | PubMed |
description | Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive disorder affecting <1/1,000,000 people. It is caused by mutations in the CLDN16 (FHHNC Type 1) or CLDN19 (FHHNC Type 2) genes, which are located on Chromosomes 3q27 and 1p34.2, respectively. There are no drug therapies for this condition. Although magnesium salts represent an important class of compounds and exhibit various therapeutic actions as a supplement for magnesium deficiency in FHHNC, various formulations on the market have different bioavailability. We report the case of a patient with FHNNC first treated, in our Pediatric Institute, with high doses of magnesium pidolate and magnesium and potassium citrate. The patient began to neglect this therapy after experiencing frequent daily episodes of diarrhoea. Our pharmacy received a request for an alternative magnesium supplement that would better comply by ensuring a good magnesium intake which will result in adequate blood magnesium levels. In response, we developed a galenic compound in the form of effervescent magnesium. Here, we report on the promise of this formulation not only for better compliance than pidolate, but also for better bioavailability. |
format | Online Article Text |
id | pubmed-10305453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103054532023-06-29 Compounded Effervescent Magnesium for Familial Hypomagnesemia: A Case Report Bennati, Giada Cirino, Mario Benericetti, Giulia Maximova, Natalia Zanier, Monica Pigato, Federico Parzianello, Anna Maestro, Alessandra Barbi, Egidio Zanon, Davide Pharmaceuticals (Basel) Case Report Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive disorder affecting <1/1,000,000 people. It is caused by mutations in the CLDN16 (FHHNC Type 1) or CLDN19 (FHHNC Type 2) genes, which are located on Chromosomes 3q27 and 1p34.2, respectively. There are no drug therapies for this condition. Although magnesium salts represent an important class of compounds and exhibit various therapeutic actions as a supplement for magnesium deficiency in FHHNC, various formulations on the market have different bioavailability. We report the case of a patient with FHNNC first treated, in our Pediatric Institute, with high doses of magnesium pidolate and magnesium and potassium citrate. The patient began to neglect this therapy after experiencing frequent daily episodes of diarrhoea. Our pharmacy received a request for an alternative magnesium supplement that would better comply by ensuring a good magnesium intake which will result in adequate blood magnesium levels. In response, we developed a galenic compound in the form of effervescent magnesium. Here, we report on the promise of this formulation not only for better compliance than pidolate, but also for better bioavailability. MDPI 2023-05-24 /pmc/articles/PMC10305453/ /pubmed/37375733 http://dx.doi.org/10.3390/ph16060785 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Bennati, Giada Cirino, Mario Benericetti, Giulia Maximova, Natalia Zanier, Monica Pigato, Federico Parzianello, Anna Maestro, Alessandra Barbi, Egidio Zanon, Davide Compounded Effervescent Magnesium for Familial Hypomagnesemia: A Case Report |
title | Compounded Effervescent Magnesium for Familial Hypomagnesemia: A Case Report |
title_full | Compounded Effervescent Magnesium for Familial Hypomagnesemia: A Case Report |
title_fullStr | Compounded Effervescent Magnesium for Familial Hypomagnesemia: A Case Report |
title_full_unstemmed | Compounded Effervescent Magnesium for Familial Hypomagnesemia: A Case Report |
title_short | Compounded Effervescent Magnesium for Familial Hypomagnesemia: A Case Report |
title_sort | compounded effervescent magnesium for familial hypomagnesemia: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305453/ https://www.ncbi.nlm.nih.gov/pubmed/37375733 http://dx.doi.org/10.3390/ph16060785 |
work_keys_str_mv | AT bennatigiada compoundedeffervescentmagnesiumforfamilialhypomagnesemiaacasereport AT cirinomario compoundedeffervescentmagnesiumforfamilialhypomagnesemiaacasereport AT benericettigiulia compoundedeffervescentmagnesiumforfamilialhypomagnesemiaacasereport AT maximovanatalia compoundedeffervescentmagnesiumforfamilialhypomagnesemiaacasereport AT zaniermonica compoundedeffervescentmagnesiumforfamilialhypomagnesemiaacasereport AT pigatofederico compoundedeffervescentmagnesiumforfamilialhypomagnesemiaacasereport AT parzianelloanna compoundedeffervescentmagnesiumforfamilialhypomagnesemiaacasereport AT maestroalessandra compoundedeffervescentmagnesiumforfamilialhypomagnesemiaacasereport AT barbiegidio compoundedeffervescentmagnesiumforfamilialhypomagnesemiaacasereport AT zanondavide compoundedeffervescentmagnesiumforfamilialhypomagnesemiaacasereport |