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Current Therapy of Chronic Viral Hepatitis B, C and D

The majority of chronic viral hepatitis cases are induced via infection with the hepatitis B virus (HBV), hepatitis C virus (HCV), or hepatitis D virus (HDV). These patients are at increased risk for progressive liver disease leading to cirrhosis as well as hepatocellular carcinoma (HCC). HBV infect...

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Autor principal: Schlaak, Jörg F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305460/
https://www.ncbi.nlm.nih.gov/pubmed/37373953
http://dx.doi.org/10.3390/jpm13060964
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author Schlaak, Jörg F.
author_facet Schlaak, Jörg F.
author_sort Schlaak, Jörg F.
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description The majority of chronic viral hepatitis cases are induced via infection with the hepatitis B virus (HBV), hepatitis C virus (HCV), or hepatitis D virus (HDV). These patients are at increased risk for progressive liver disease leading to cirrhosis as well as hepatocellular carcinoma (HCC). HBV infection is well controlled by the currently available nucleosides as well as nucleotides, and the development of cirrhosis can be prevented. Additionally, it has been shown that HBV-induced liver fibrosis can regress during successful antiviral treatment; however, a “functional cure”, i.e., loss of HBsAg, is a rare event when these drugs are used. Therefore, novel therapeutic strategies are aiming at the selective suppression of HBsAg levels in combination with immunostimulation. The development of directly acting antivirals (DAAs) has revolutionized HCV therapy, as almost all patients can be cured via this treatment. Additionally, DAA therapy has few, if any, side effects, and is generally well tolerated by patients. HDV remains the most challenging type of chronic viral hepatitis. Although novel therapeutic options have recently been approved, response rates are still less favorable compared to HBV and HCV. This review discusses current and future options for the treatment of chronic HBV, HCV, and HDV infection.
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spelling pubmed-103054602023-06-29 Current Therapy of Chronic Viral Hepatitis B, C and D Schlaak, Jörg F. J Pers Med Review The majority of chronic viral hepatitis cases are induced via infection with the hepatitis B virus (HBV), hepatitis C virus (HCV), or hepatitis D virus (HDV). These patients are at increased risk for progressive liver disease leading to cirrhosis as well as hepatocellular carcinoma (HCC). HBV infection is well controlled by the currently available nucleosides as well as nucleotides, and the development of cirrhosis can be prevented. Additionally, it has been shown that HBV-induced liver fibrosis can regress during successful antiviral treatment; however, a “functional cure”, i.e., loss of HBsAg, is a rare event when these drugs are used. Therefore, novel therapeutic strategies are aiming at the selective suppression of HBsAg levels in combination with immunostimulation. The development of directly acting antivirals (DAAs) has revolutionized HCV therapy, as almost all patients can be cured via this treatment. Additionally, DAA therapy has few, if any, side effects, and is generally well tolerated by patients. HDV remains the most challenging type of chronic viral hepatitis. Although novel therapeutic options have recently been approved, response rates are still less favorable compared to HBV and HCV. This review discusses current and future options for the treatment of chronic HBV, HCV, and HDV infection. MDPI 2023-06-07 /pmc/articles/PMC10305460/ /pubmed/37373953 http://dx.doi.org/10.3390/jpm13060964 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schlaak, Jörg F.
Current Therapy of Chronic Viral Hepatitis B, C and D
title Current Therapy of Chronic Viral Hepatitis B, C and D
title_full Current Therapy of Chronic Viral Hepatitis B, C and D
title_fullStr Current Therapy of Chronic Viral Hepatitis B, C and D
title_full_unstemmed Current Therapy of Chronic Viral Hepatitis B, C and D
title_short Current Therapy of Chronic Viral Hepatitis B, C and D
title_sort current therapy of chronic viral hepatitis b, c and d
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305460/
https://www.ncbi.nlm.nih.gov/pubmed/37373953
http://dx.doi.org/10.3390/jpm13060964
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