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Current Knowledge on Epizootic Haemorrhagic Disease in China
Epizootic haemorrhagic disease (EHD) is an infectious, non-contagious viral disease of ruminants caused by epizootic haemorrhagic disease virus (EHDV) and is transmitted by insects of the genus Culicoides. In 2008, EHD was listed on the World Organization for Animal Health (WOAH) list of notifiable...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305533/ https://www.ncbi.nlm.nih.gov/pubmed/37376512 http://dx.doi.org/10.3390/vaccines11061123 |
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author | Xin, Jige Dong, Jun Li, Jing Ye, Lingling Zhang, Chong Nie, Fuping Gu, Yeqing Ji, Xincheng Song, Zhigang Luo, Qianmin Ai, Jun Han, Diangang |
author_facet | Xin, Jige Dong, Jun Li, Jing Ye, Lingling Zhang, Chong Nie, Fuping Gu, Yeqing Ji, Xincheng Song, Zhigang Luo, Qianmin Ai, Jun Han, Diangang |
author_sort | Xin, Jige |
collection | PubMed |
description | Epizootic haemorrhagic disease (EHD) is an infectious, non-contagious viral disease of ruminants caused by epizootic haemorrhagic disease virus (EHDV) and is transmitted by insects of the genus Culicoides. In 2008, EHD was listed on the World Organization for Animal Health (WOAH) list of notifiable terrestrial and aquatic animal diseases. This article reviews the distribution of EHD in China and relevant studies and proposes several suggestions for the prevention and control of EHD. There have been reports of positivity for serum antibodies against EHDV-1, EHDV-2, EHDV-5, EHDV-6, EHDV-7, EHDV-8 and EHDV-10 in China. Strains of EHDV-1, -5, -6, -7, -8 and -10 have been isolated, among which the Seg-2, Seg-3 and Seg-6 sequences of serotypes -5, -6, -7 and -10 belong to the eastern topotype. The emergence of western topotype Seg-2 in EHDV-1 strains indicates that EHDV-1 strains in China are reassortant strains of the western and eastern topotypes. A novel serotype strain of EHDV named YNDH/V079/2018 was isolated in 2018. Chinese scholars have successfully expressed the EHDV VP7 protein and developed a variety of ELISA detection methods, including antigen capture ELISA and competitive ELISA. A variety of EHDV nucleic acid detection methods, including RT–PCR and qRT–PCR, have also been developed. LAMP and the liquid chip detection technique are also available. To prevent and control EHD, several suggestions for controlling EHD transmission have been proposed based on the actual situation in China, including controlling the number of Culicoides, reducing contact between Culicoides and hosts, continued monitoring of EHDV and Culicoides in different areas of China and further development and application of basic and pioneering research related to EHD prevention and control. |
format | Online Article Text |
id | pubmed-10305533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103055332023-06-29 Current Knowledge on Epizootic Haemorrhagic Disease in China Xin, Jige Dong, Jun Li, Jing Ye, Lingling Zhang, Chong Nie, Fuping Gu, Yeqing Ji, Xincheng Song, Zhigang Luo, Qianmin Ai, Jun Han, Diangang Vaccines (Basel) Review Epizootic haemorrhagic disease (EHD) is an infectious, non-contagious viral disease of ruminants caused by epizootic haemorrhagic disease virus (EHDV) and is transmitted by insects of the genus Culicoides. In 2008, EHD was listed on the World Organization for Animal Health (WOAH) list of notifiable terrestrial and aquatic animal diseases. This article reviews the distribution of EHD in China and relevant studies and proposes several suggestions for the prevention and control of EHD. There have been reports of positivity for serum antibodies against EHDV-1, EHDV-2, EHDV-5, EHDV-6, EHDV-7, EHDV-8 and EHDV-10 in China. Strains of EHDV-1, -5, -6, -7, -8 and -10 have been isolated, among which the Seg-2, Seg-3 and Seg-6 sequences of serotypes -5, -6, -7 and -10 belong to the eastern topotype. The emergence of western topotype Seg-2 in EHDV-1 strains indicates that EHDV-1 strains in China are reassortant strains of the western and eastern topotypes. A novel serotype strain of EHDV named YNDH/V079/2018 was isolated in 2018. Chinese scholars have successfully expressed the EHDV VP7 protein and developed a variety of ELISA detection methods, including antigen capture ELISA and competitive ELISA. A variety of EHDV nucleic acid detection methods, including RT–PCR and qRT–PCR, have also been developed. LAMP and the liquid chip detection technique are also available. To prevent and control EHD, several suggestions for controlling EHD transmission have been proposed based on the actual situation in China, including controlling the number of Culicoides, reducing contact between Culicoides and hosts, continued monitoring of EHDV and Culicoides in different areas of China and further development and application of basic and pioneering research related to EHD prevention and control. MDPI 2023-06-20 /pmc/articles/PMC10305533/ /pubmed/37376512 http://dx.doi.org/10.3390/vaccines11061123 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Xin, Jige Dong, Jun Li, Jing Ye, Lingling Zhang, Chong Nie, Fuping Gu, Yeqing Ji, Xincheng Song, Zhigang Luo, Qianmin Ai, Jun Han, Diangang Current Knowledge on Epizootic Haemorrhagic Disease in China |
title | Current Knowledge on Epizootic Haemorrhagic Disease in China |
title_full | Current Knowledge on Epizootic Haemorrhagic Disease in China |
title_fullStr | Current Knowledge on Epizootic Haemorrhagic Disease in China |
title_full_unstemmed | Current Knowledge on Epizootic Haemorrhagic Disease in China |
title_short | Current Knowledge on Epizootic Haemorrhagic Disease in China |
title_sort | current knowledge on epizootic haemorrhagic disease in china |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305533/ https://www.ncbi.nlm.nih.gov/pubmed/37376512 http://dx.doi.org/10.3390/vaccines11061123 |
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