Querying Recombination Junctions of Replication-Competent Adeno-Associated Viruses in Gene Therapy Vector Preparations with Single Molecule, Real-Time Sequencing

Clinical-grade preparations of adeno-associated virus (AAV) vectors used for gene therapy typically undergo a series of diagnostics to determine titer, purity, homogeneity, and the presence of DNA contaminants. One type of contaminant that remains poorly investigated is replication-competent (rc)AAV...

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Detalles Bibliográficos
Autores principales: Yip, Mitchell, Chen, Jing, Zhi, Yan, Tran, Ngoc Tam, Namkung, Suk, Pastor, Eric, Gao, Guangping, Tai, Phillip W. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305535/
https://www.ncbi.nlm.nih.gov/pubmed/37376529
http://dx.doi.org/10.3390/v15061228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305535/
https://www.ncbi.nlm.nih.gov/pubmed/37376529
http://dx.doi.org/10.3390/v15061228

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