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New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children
Aim: This study evaluated the relationship between the systemic immune–inflammatory index (SII), neutrophil–to–lymphocyte ratio (NLR), and platelet–to–lymphocyte ratio (PLR) with clinical findings of respiratory syncytial virus (RSV) infection among children with a diagnosis of lower respiratory tra...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305612/ https://www.ncbi.nlm.nih.gov/pubmed/37376545 http://dx.doi.org/10.3390/v15061245 |
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author | Okuyan, Omer Elgormus, Yusuf Dumur, Seyma Sayili, Ugurcan Uzun, Hafize |
author_facet | Okuyan, Omer Elgormus, Yusuf Dumur, Seyma Sayili, Ugurcan Uzun, Hafize |
author_sort | Okuyan, Omer |
collection | PubMed |
description | Aim: This study evaluated the relationship between the systemic immune–inflammatory index (SII), neutrophil–to–lymphocyte ratio (NLR), and platelet–to–lymphocyte ratio (PLR) with clinical findings of respiratory syncytial virus (RSV) infection among children with a diagnosis of lower respiratory tract infection (LRTI). Methods: The study was conducted between 1 January 2020 and 1 January 2022 in a pediatric clinic. This retrospective study included 286 consecutive patients between 0 and 12 years of age, 138 of whom were RSV (+) (48.25%) and 148 of whom were RSV (−) (51.75%). The detection of the RSV antigen was carried out using the chromatographic immunoassay method on nasopharyngeal swabbing samples. Results: CRP content was significantly higher in patients with RSV (+) than in children with RSV (−), while NLR, PLR, and SII, as inflammatory parameters, were significantly lower. Fever, coughs, and wheezing were the most common symptoms in the RSV (+) groups (100%). RSV infections were the highest in November, October, and December, in that order. The AUC was statistically significant for parameters in all groups. AUC values were 0.841 (95%: 0.765–0.917) for leukocytes, 0.703 (95%: 0.618–0.788) for lymphocytes, 0.869 (95%: 0.800–0.937) for CRP, 0.706 (95%: 0.636–0.776) for NLR, 0.779 (95%: 0.722–0.836) for PLR, and 0.705 (95%: 0.633–0.776) for SII. CRP was found to have both high sensitivity (80.4%) and high specificity (82.4%) among all parameters. While the ROC analysis results showed similar results for children under two years old, only CRP and NLR were statistically significant in this group. Conclusion: CRP performed better than other blood parameters as a marker. The NLR, PLR, and SII index were significantly lower in LRTI patients with RSV (+) than in those with RSV (−), which implies a higher grade of inflammation. If the cause of the disease can be determined by this method, disease management will be easier, and unnecessary antibiotics could be avoided. |
format | Online Article Text |
id | pubmed-10305612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103056122023-06-29 New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children Okuyan, Omer Elgormus, Yusuf Dumur, Seyma Sayili, Ugurcan Uzun, Hafize Viruses Article Aim: This study evaluated the relationship between the systemic immune–inflammatory index (SII), neutrophil–to–lymphocyte ratio (NLR), and platelet–to–lymphocyte ratio (PLR) with clinical findings of respiratory syncytial virus (RSV) infection among children with a diagnosis of lower respiratory tract infection (LRTI). Methods: The study was conducted between 1 January 2020 and 1 January 2022 in a pediatric clinic. This retrospective study included 286 consecutive patients between 0 and 12 years of age, 138 of whom were RSV (+) (48.25%) and 148 of whom were RSV (−) (51.75%). The detection of the RSV antigen was carried out using the chromatographic immunoassay method on nasopharyngeal swabbing samples. Results: CRP content was significantly higher in patients with RSV (+) than in children with RSV (−), while NLR, PLR, and SII, as inflammatory parameters, were significantly lower. Fever, coughs, and wheezing were the most common symptoms in the RSV (+) groups (100%). RSV infections were the highest in November, October, and December, in that order. The AUC was statistically significant for parameters in all groups. AUC values were 0.841 (95%: 0.765–0.917) for leukocytes, 0.703 (95%: 0.618–0.788) for lymphocytes, 0.869 (95%: 0.800–0.937) for CRP, 0.706 (95%: 0.636–0.776) for NLR, 0.779 (95%: 0.722–0.836) for PLR, and 0.705 (95%: 0.633–0.776) for SII. CRP was found to have both high sensitivity (80.4%) and high specificity (82.4%) among all parameters. While the ROC analysis results showed similar results for children under two years old, only CRP and NLR were statistically significant in this group. Conclusion: CRP performed better than other blood parameters as a marker. The NLR, PLR, and SII index were significantly lower in LRTI patients with RSV (+) than in those with RSV (−), which implies a higher grade of inflammation. If the cause of the disease can be determined by this method, disease management will be easier, and unnecessary antibiotics could be avoided. MDPI 2023-05-25 /pmc/articles/PMC10305612/ /pubmed/37376545 http://dx.doi.org/10.3390/v15061245 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Okuyan, Omer Elgormus, Yusuf Dumur, Seyma Sayili, Ugurcan Uzun, Hafize New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children |
title | New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children |
title_full | New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children |
title_fullStr | New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children |
title_full_unstemmed | New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children |
title_short | New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children |
title_sort | new generation of systemic inflammatory markers for respiratory syncytial virus infection in children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305612/ https://www.ncbi.nlm.nih.gov/pubmed/37376545 http://dx.doi.org/10.3390/v15061245 |
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