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New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children

Aim: This study evaluated the relationship between the systemic immune–inflammatory index (SII), neutrophil–to–lymphocyte ratio (NLR), and platelet–to–lymphocyte ratio (PLR) with clinical findings of respiratory syncytial virus (RSV) infection among children with a diagnosis of lower respiratory tra...

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Autores principales: Okuyan, Omer, Elgormus, Yusuf, Dumur, Seyma, Sayili, Ugurcan, Uzun, Hafize
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305612/
https://www.ncbi.nlm.nih.gov/pubmed/37376545
http://dx.doi.org/10.3390/v15061245
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author Okuyan, Omer
Elgormus, Yusuf
Dumur, Seyma
Sayili, Ugurcan
Uzun, Hafize
author_facet Okuyan, Omer
Elgormus, Yusuf
Dumur, Seyma
Sayili, Ugurcan
Uzun, Hafize
author_sort Okuyan, Omer
collection PubMed
description Aim: This study evaluated the relationship between the systemic immune–inflammatory index (SII), neutrophil–to–lymphocyte ratio (NLR), and platelet–to–lymphocyte ratio (PLR) with clinical findings of respiratory syncytial virus (RSV) infection among children with a diagnosis of lower respiratory tract infection (LRTI). Methods: The study was conducted between 1 January 2020 and 1 January 2022 in a pediatric clinic. This retrospective study included 286 consecutive patients between 0 and 12 years of age, 138 of whom were RSV (+) (48.25%) and 148 of whom were RSV (−) (51.75%). The detection of the RSV antigen was carried out using the chromatographic immunoassay method on nasopharyngeal swabbing samples. Results: CRP content was significantly higher in patients with RSV (+) than in children with RSV (−), while NLR, PLR, and SII, as inflammatory parameters, were significantly lower. Fever, coughs, and wheezing were the most common symptoms in the RSV (+) groups (100%). RSV infections were the highest in November, October, and December, in that order. The AUC was statistically significant for parameters in all groups. AUC values were 0.841 (95%: 0.765–0.917) for leukocytes, 0.703 (95%: 0.618–0.788) for lymphocytes, 0.869 (95%: 0.800–0.937) for CRP, 0.706 (95%: 0.636–0.776) for NLR, 0.779 (95%: 0.722–0.836) for PLR, and 0.705 (95%: 0.633–0.776) for SII. CRP was found to have both high sensitivity (80.4%) and high specificity (82.4%) among all parameters. While the ROC analysis results showed similar results for children under two years old, only CRP and NLR were statistically significant in this group. Conclusion: CRP performed better than other blood parameters as a marker. The NLR, PLR, and SII index were significantly lower in LRTI patients with RSV (+) than in those with RSV (−), which implies a higher grade of inflammation. If the cause of the disease can be determined by this method, disease management will be easier, and unnecessary antibiotics could be avoided.
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spelling pubmed-103056122023-06-29 New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children Okuyan, Omer Elgormus, Yusuf Dumur, Seyma Sayili, Ugurcan Uzun, Hafize Viruses Article Aim: This study evaluated the relationship between the systemic immune–inflammatory index (SII), neutrophil–to–lymphocyte ratio (NLR), and platelet–to–lymphocyte ratio (PLR) with clinical findings of respiratory syncytial virus (RSV) infection among children with a diagnosis of lower respiratory tract infection (LRTI). Methods: The study was conducted between 1 January 2020 and 1 January 2022 in a pediatric clinic. This retrospective study included 286 consecutive patients between 0 and 12 years of age, 138 of whom were RSV (+) (48.25%) and 148 of whom were RSV (−) (51.75%). The detection of the RSV antigen was carried out using the chromatographic immunoassay method on nasopharyngeal swabbing samples. Results: CRP content was significantly higher in patients with RSV (+) than in children with RSV (−), while NLR, PLR, and SII, as inflammatory parameters, were significantly lower. Fever, coughs, and wheezing were the most common symptoms in the RSV (+) groups (100%). RSV infections were the highest in November, October, and December, in that order. The AUC was statistically significant for parameters in all groups. AUC values were 0.841 (95%: 0.765–0.917) for leukocytes, 0.703 (95%: 0.618–0.788) for lymphocytes, 0.869 (95%: 0.800–0.937) for CRP, 0.706 (95%: 0.636–0.776) for NLR, 0.779 (95%: 0.722–0.836) for PLR, and 0.705 (95%: 0.633–0.776) for SII. CRP was found to have both high sensitivity (80.4%) and high specificity (82.4%) among all parameters. While the ROC analysis results showed similar results for children under two years old, only CRP and NLR were statistically significant in this group. Conclusion: CRP performed better than other blood parameters as a marker. The NLR, PLR, and SII index were significantly lower in LRTI patients with RSV (+) than in those with RSV (−), which implies a higher grade of inflammation. If the cause of the disease can be determined by this method, disease management will be easier, and unnecessary antibiotics could be avoided. MDPI 2023-05-25 /pmc/articles/PMC10305612/ /pubmed/37376545 http://dx.doi.org/10.3390/v15061245 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Okuyan, Omer
Elgormus, Yusuf
Dumur, Seyma
Sayili, Ugurcan
Uzun, Hafize
New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children
title New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children
title_full New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children
title_fullStr New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children
title_full_unstemmed New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children
title_short New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children
title_sort new generation of systemic inflammatory markers for respiratory syncytial virus infection in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305612/
https://www.ncbi.nlm.nih.gov/pubmed/37376545
http://dx.doi.org/10.3390/v15061245
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