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Tensins in Kidney Function and Diseases

Tensins are focal adhesion proteins that regulate various biological processes, such as mechanical sensing, cell adhesion, migration, invasion, and proliferation, through their multiple binding activities that transduce critical signals across the plasma membrane. When these molecular interactions a...

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Detalles Bibliográficos
Autores principales: Huang, Chien-Wei, Lo, Su Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305691/
https://www.ncbi.nlm.nih.gov/pubmed/37374025
http://dx.doi.org/10.3390/life13061244
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author Huang, Chien-Wei
Lo, Su Hao
author_facet Huang, Chien-Wei
Lo, Su Hao
author_sort Huang, Chien-Wei
collection PubMed
description Tensins are focal adhesion proteins that regulate various biological processes, such as mechanical sensing, cell adhesion, migration, invasion, and proliferation, through their multiple binding activities that transduce critical signals across the plasma membrane. When these molecular interactions and/or mediated signaling are disrupted, cellular activities and tissue functions are compromised, leading to disease development. Here, we focus on the significance of the tensin family in renal function and diseases. The expression pattern of each tensin in the kidney, their roles in chronic kidney diseases, renal cell carcinoma, and their potentials as prognostic markers and/or therapeutic targets are discussed in this review.
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spelling pubmed-103056912023-06-29 Tensins in Kidney Function and Diseases Huang, Chien-Wei Lo, Su Hao Life (Basel) Review Tensins are focal adhesion proteins that regulate various biological processes, such as mechanical sensing, cell adhesion, migration, invasion, and proliferation, through their multiple binding activities that transduce critical signals across the plasma membrane. When these molecular interactions and/or mediated signaling are disrupted, cellular activities and tissue functions are compromised, leading to disease development. Here, we focus on the significance of the tensin family in renal function and diseases. The expression pattern of each tensin in the kidney, their roles in chronic kidney diseases, renal cell carcinoma, and their potentials as prognostic markers and/or therapeutic targets are discussed in this review. MDPI 2023-05-24 /pmc/articles/PMC10305691/ /pubmed/37374025 http://dx.doi.org/10.3390/life13061244 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huang, Chien-Wei
Lo, Su Hao
Tensins in Kidney Function and Diseases
title Tensins in Kidney Function and Diseases
title_full Tensins in Kidney Function and Diseases
title_fullStr Tensins in Kidney Function and Diseases
title_full_unstemmed Tensins in Kidney Function and Diseases
title_short Tensins in Kidney Function and Diseases
title_sort tensins in kidney function and diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305691/
https://www.ncbi.nlm.nih.gov/pubmed/37374025
http://dx.doi.org/10.3390/life13061244
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