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Tensins in Kidney Function and Diseases
Tensins are focal adhesion proteins that regulate various biological processes, such as mechanical sensing, cell adhesion, migration, invasion, and proliferation, through their multiple binding activities that transduce critical signals across the plasma membrane. When these molecular interactions a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305691/ https://www.ncbi.nlm.nih.gov/pubmed/37374025 http://dx.doi.org/10.3390/life13061244 |
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author | Huang, Chien-Wei Lo, Su Hao |
author_facet | Huang, Chien-Wei Lo, Su Hao |
author_sort | Huang, Chien-Wei |
collection | PubMed |
description | Tensins are focal adhesion proteins that regulate various biological processes, such as mechanical sensing, cell adhesion, migration, invasion, and proliferation, through their multiple binding activities that transduce critical signals across the plasma membrane. When these molecular interactions and/or mediated signaling are disrupted, cellular activities and tissue functions are compromised, leading to disease development. Here, we focus on the significance of the tensin family in renal function and diseases. The expression pattern of each tensin in the kidney, their roles in chronic kidney diseases, renal cell carcinoma, and their potentials as prognostic markers and/or therapeutic targets are discussed in this review. |
format | Online Article Text |
id | pubmed-10305691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103056912023-06-29 Tensins in Kidney Function and Diseases Huang, Chien-Wei Lo, Su Hao Life (Basel) Review Tensins are focal adhesion proteins that regulate various biological processes, such as mechanical sensing, cell adhesion, migration, invasion, and proliferation, through their multiple binding activities that transduce critical signals across the plasma membrane. When these molecular interactions and/or mediated signaling are disrupted, cellular activities and tissue functions are compromised, leading to disease development. Here, we focus on the significance of the tensin family in renal function and diseases. The expression pattern of each tensin in the kidney, their roles in chronic kidney diseases, renal cell carcinoma, and their potentials as prognostic markers and/or therapeutic targets are discussed in this review. MDPI 2023-05-24 /pmc/articles/PMC10305691/ /pubmed/37374025 http://dx.doi.org/10.3390/life13061244 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Huang, Chien-Wei Lo, Su Hao Tensins in Kidney Function and Diseases |
title | Tensins in Kidney Function and Diseases |
title_full | Tensins in Kidney Function and Diseases |
title_fullStr | Tensins in Kidney Function and Diseases |
title_full_unstemmed | Tensins in Kidney Function and Diseases |
title_short | Tensins in Kidney Function and Diseases |
title_sort | tensins in kidney function and diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305691/ https://www.ncbi.nlm.nih.gov/pubmed/37374025 http://dx.doi.org/10.3390/life13061244 |
work_keys_str_mv | AT huangchienwei tensinsinkidneyfunctionanddiseases AT losuhao tensinsinkidneyfunctionanddiseases |