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Electroencephalography microstates imbalance across the spectrum of early psychosis, autism, and mood disorders
BACKGROUND: Electroencephalography (EEG) microstates translate resting-state temporal dynamics of neuronal networks throughout the brain and could constitute possible markers of psychiatric disorders. We tested the hypothesis of an increased imbalance between a predominant self-referential mode (mic...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305759/ https://www.ncbi.nlm.nih.gov/pubmed/37246142 http://dx.doi.org/10.1192/j.eurpsy.2023.2414 |
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author | Iftimovici, Anton Marchi, Angela Férat, Victor Pruvost-Robieux, Estelle Guinard, Eléonore Morin, Valentine Elandaloussi, Yannis D’Halluin, Arnaud Krebs, Marie-Odile Chaumette, Boris Gavaret, Martine |
author_facet | Iftimovici, Anton Marchi, Angela Férat, Victor Pruvost-Robieux, Estelle Guinard, Eléonore Morin, Valentine Elandaloussi, Yannis D’Halluin, Arnaud Krebs, Marie-Odile Chaumette, Boris Gavaret, Martine |
author_sort | Iftimovici, Anton |
collection | PubMed |
description | BACKGROUND: Electroencephalography (EEG) microstates translate resting-state temporal dynamics of neuronal networks throughout the brain and could constitute possible markers of psychiatric disorders. We tested the hypothesis of an increased imbalance between a predominant self-referential mode (microstate C) and a decreased attentional mode (microstate D) in psychosis, mood, and autism spectrum disorders. METHODS: We retrospectively included 135 subjects from an early psychosis outpatient unit, with available eyes-closed resting-state 19 electrodes EEG. Individual-level then group-level modified K-means clustering in controls provided four microstate maps that were then backfitted to all groups. Differences between microstate parameters (occurrence, coverage, and mean duration) were computed between controls and each group, and between disease groups. RESULTS: Microstate class D parameters were systematically decreased in disease groups compared with controls, with an effect size increasing along the psychosis spectrum, but also in autism. There was no difference in class C. C/D ratios of mean duration were increased only in SCZ compared with controls. CONCLUSIONS: The decrease in microstate class D may be a marker of stage of psychosis, but it is not specific to it and may rather reflect a shared dimension along the schizophrenia-autism spectrum. C/D microstate imbalance may be more specific to schizophrenia. |
format | Online Article Text |
id | pubmed-10305759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103057592023-06-29 Electroencephalography microstates imbalance across the spectrum of early psychosis, autism, and mood disorders Iftimovici, Anton Marchi, Angela Férat, Victor Pruvost-Robieux, Estelle Guinard, Eléonore Morin, Valentine Elandaloussi, Yannis D’Halluin, Arnaud Krebs, Marie-Odile Chaumette, Boris Gavaret, Martine Eur Psychiatry Research Article BACKGROUND: Electroencephalography (EEG) microstates translate resting-state temporal dynamics of neuronal networks throughout the brain and could constitute possible markers of psychiatric disorders. We tested the hypothesis of an increased imbalance between a predominant self-referential mode (microstate C) and a decreased attentional mode (microstate D) in psychosis, mood, and autism spectrum disorders. METHODS: We retrospectively included 135 subjects from an early psychosis outpatient unit, with available eyes-closed resting-state 19 electrodes EEG. Individual-level then group-level modified K-means clustering in controls provided four microstate maps that were then backfitted to all groups. Differences between microstate parameters (occurrence, coverage, and mean duration) were computed between controls and each group, and between disease groups. RESULTS: Microstate class D parameters were systematically decreased in disease groups compared with controls, with an effect size increasing along the psychosis spectrum, but also in autism. There was no difference in class C. C/D ratios of mean duration were increased only in SCZ compared with controls. CONCLUSIONS: The decrease in microstate class D may be a marker of stage of psychosis, but it is not specific to it and may rather reflect a shared dimension along the schizophrenia-autism spectrum. C/D microstate imbalance may be more specific to schizophrenia. Cambridge University Press 2023-05-29 /pmc/articles/PMC10305759/ /pubmed/37246142 http://dx.doi.org/10.1192/j.eurpsy.2023.2414 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
spellingShingle | Research Article Iftimovici, Anton Marchi, Angela Férat, Victor Pruvost-Robieux, Estelle Guinard, Eléonore Morin, Valentine Elandaloussi, Yannis D’Halluin, Arnaud Krebs, Marie-Odile Chaumette, Boris Gavaret, Martine Electroencephalography microstates imbalance across the spectrum of early psychosis, autism, and mood disorders |
title | Electroencephalography microstates imbalance across the spectrum of early psychosis, autism, and mood disorders |
title_full | Electroencephalography microstates imbalance across the spectrum of early psychosis, autism, and mood disorders |
title_fullStr | Electroencephalography microstates imbalance across the spectrum of early psychosis, autism, and mood disorders |
title_full_unstemmed | Electroencephalography microstates imbalance across the spectrum of early psychosis, autism, and mood disorders |
title_short | Electroencephalography microstates imbalance across the spectrum of early psychosis, autism, and mood disorders |
title_sort | electroencephalography microstates imbalance across the spectrum of early psychosis, autism, and mood disorders |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305759/ https://www.ncbi.nlm.nih.gov/pubmed/37246142 http://dx.doi.org/10.1192/j.eurpsy.2023.2414 |
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