Cargando…

Phenotypic Interindividual Differences in the Dynamic Structure of Sleep in Healthy Young Adults

INTRODUCTION: Evaluating the dynamic structure of sleep may yield new insights into the mechanisms underlying human sleep physiology. METHODS: We analyzed data from a 12-day, 11-night, strictly controlled laboratory study with an adaptation night, 3 iterations of a baseline night followed by a recov...

Descripción completa

Detalles Bibliográficos
Autores principales: Kishi, Akifumi, Van Dongen, Hans P A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305769/
https://www.ncbi.nlm.nih.gov/pubmed/37388963
http://dx.doi.org/10.2147/NSS.S392038
_version_ 1785065809066852352
author Kishi, Akifumi
Van Dongen, Hans P A
author_facet Kishi, Akifumi
Van Dongen, Hans P A
author_sort Kishi, Akifumi
collection PubMed
description INTRODUCTION: Evaluating the dynamic structure of sleep may yield new insights into the mechanisms underlying human sleep physiology. METHODS: We analyzed data from a 12-day, 11-night, strictly controlled laboratory study with an adaptation night, 3 iterations of a baseline night followed by a recovery night after 36 h of total sleep deprivation, and a final recovery night. All sleep opportunities were 12 h in duration (22:00–10:00) and recorded with polysomnography (PSG). The PSG records were scored for the sleep stages: rapid eye movement (REM) sleep; non-REM (NREM) stage 1 sleep (S1), stage 2 sleep (S2), and slow wave sleep (SWS); and wake (W). Phenotypic interindividual differences were assessed using indices of dynamic sleep structure – specifically sleep stage transitions and sleep cycle characteristics – and intraclass correlation coefficients across nights. RESULTS: NREM/REM sleep cycles and sleep stage transitions exhibited substantial and stable interindividual differences that were robust across baseline and recovery nights, suggesting that mechanisms underlying the dynamic structure of sleep are phenotypic. In addition, the dynamics of sleep stage transitions were found to be associated with sleep cycle characteristics, with a significant relationship between the length of sleep cycles and the degree to which S2-to-W/S1 and S2-to-SWS transitions were in equilibrium. DISCUSSION: Our findings are consistent with a model for the underlying mechanisms that involves three subsystems – characterized by S2-to-W/S1, S2-to-SWS, and S2-to-REM transitions – with S2 playing a hub-like role. Furthermore, the balance between the two subsystems within NREM sleep (S2-to-W/S1 and S2-to-SWS) may serve as a basis for the dynamic regulation of sleep structure and may represent a novel target for interventions aiming to improve sleep.
format Online
Article
Text
id pubmed-10305769
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-103057692023-06-29 Phenotypic Interindividual Differences in the Dynamic Structure of Sleep in Healthy Young Adults Kishi, Akifumi Van Dongen, Hans P A Nat Sci Sleep Original Research INTRODUCTION: Evaluating the dynamic structure of sleep may yield new insights into the mechanisms underlying human sleep physiology. METHODS: We analyzed data from a 12-day, 11-night, strictly controlled laboratory study with an adaptation night, 3 iterations of a baseline night followed by a recovery night after 36 h of total sleep deprivation, and a final recovery night. All sleep opportunities were 12 h in duration (22:00–10:00) and recorded with polysomnography (PSG). The PSG records were scored for the sleep stages: rapid eye movement (REM) sleep; non-REM (NREM) stage 1 sleep (S1), stage 2 sleep (S2), and slow wave sleep (SWS); and wake (W). Phenotypic interindividual differences were assessed using indices of dynamic sleep structure – specifically sleep stage transitions and sleep cycle characteristics – and intraclass correlation coefficients across nights. RESULTS: NREM/REM sleep cycles and sleep stage transitions exhibited substantial and stable interindividual differences that were robust across baseline and recovery nights, suggesting that mechanisms underlying the dynamic structure of sleep are phenotypic. In addition, the dynamics of sleep stage transitions were found to be associated with sleep cycle characteristics, with a significant relationship between the length of sleep cycles and the degree to which S2-to-W/S1 and S2-to-SWS transitions were in equilibrium. DISCUSSION: Our findings are consistent with a model for the underlying mechanisms that involves three subsystems – characterized by S2-to-W/S1, S2-to-SWS, and S2-to-REM transitions – with S2 playing a hub-like role. Furthermore, the balance between the two subsystems within NREM sleep (S2-to-W/S1 and S2-to-SWS) may serve as a basis for the dynamic regulation of sleep structure and may represent a novel target for interventions aiming to improve sleep. Dove 2023-06-24 /pmc/articles/PMC10305769/ /pubmed/37388963 http://dx.doi.org/10.2147/NSS.S392038 Text en © 2023 Kishi and Van Dongen. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Kishi, Akifumi
Van Dongen, Hans P A
Phenotypic Interindividual Differences in the Dynamic Structure of Sleep in Healthy Young Adults
title Phenotypic Interindividual Differences in the Dynamic Structure of Sleep in Healthy Young Adults
title_full Phenotypic Interindividual Differences in the Dynamic Structure of Sleep in Healthy Young Adults
title_fullStr Phenotypic Interindividual Differences in the Dynamic Structure of Sleep in Healthy Young Adults
title_full_unstemmed Phenotypic Interindividual Differences in the Dynamic Structure of Sleep in Healthy Young Adults
title_short Phenotypic Interindividual Differences in the Dynamic Structure of Sleep in Healthy Young Adults
title_sort phenotypic interindividual differences in the dynamic structure of sleep in healthy young adults
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305769/
https://www.ncbi.nlm.nih.gov/pubmed/37388963
http://dx.doi.org/10.2147/NSS.S392038
work_keys_str_mv AT kishiakifumi phenotypicinterindividualdifferencesinthedynamicstructureofsleepinhealthyyoungadults
AT vandongenhanspa phenotypicinterindividualdifferencesinthedynamicstructureofsleepinhealthyyoungadults