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Ventilatory defects and treatable traits in very elderly patients

Though the approach used to classify chronic respiratory diseases is changing to a treatable-traits (TT) approach, data regarding very elderly patients is lacking. The objectives of this study were to assess TT frequency in very elderly patients and to study the link between extrapulmonary TT and ve...

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Autores principales: Gaspar-Marques, João, Palmeiro, Teresa, Caires, Iolanda, Leiria Pinto, Paula, Neuparth, Nuno, Carreiro-Martins, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305819/
https://www.ncbi.nlm.nih.gov/pubmed/33929910
http://dx.doi.org/10.1177/00368504211013171
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author Gaspar-Marques, João
Palmeiro, Teresa
Caires, Iolanda
Leiria Pinto, Paula
Neuparth, Nuno
Carreiro-Martins, Pedro
author_facet Gaspar-Marques, João
Palmeiro, Teresa
Caires, Iolanda
Leiria Pinto, Paula
Neuparth, Nuno
Carreiro-Martins, Pedro
author_sort Gaspar-Marques, João
collection PubMed
description Though the approach used to classify chronic respiratory diseases is changing to a treatable-traits (TT) approach, data regarding very elderly patients is lacking. The objectives of this study were to assess TT frequency in very elderly patients and to study the link between extrapulmonary TT and ventilatory defects. Individuals (≥75 years) residing in elderly care centres answered a standardised questionnaire, underwent spirometry, atopy and fractional exhaled nitric oxide assessments and had their blood pressure and peripheral pulse oximetry measured. Pulmonary, extrapulmonary and behavioural TT were evaluated. Outcome variables were an airflow limitation (post-bronchodilator z-score FEV(1)/FVC<−1.64) and a restrictive spirometry pattern (z-score FEV(1)/FVC ≥ +1.64 and z-score FVC<−1.64). Seventy-two percent of the individuals who took part in the study (n = 234) were women, and the median age of participants was 86 (IQR: 7.4). At least one pulmonary TT was identified in 105 (44.9%) individuals. The most frequent extrapulmonary TTs were: persistent systemic inflammation (47.0%), anaemia (34.4%), depression (32.5%) and obesity (27.4). Airflow limitation was exclusively associated with smoking (OR 5.03; 95% CI 1.56–16.22). A restrictive spirometry pattern was associated with cognitive impairment (OR: 3.89; 95% CI: 1.55–9.79). A high frequency of various TTs was found. The novel association between a restrictive spirometry pattern and cognitive impairment highlights the urgency of clinical research on this vulnerable age group.
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spelling pubmed-103058192023-08-09 Ventilatory defects and treatable traits in very elderly patients Gaspar-Marques, João Palmeiro, Teresa Caires, Iolanda Leiria Pinto, Paula Neuparth, Nuno Carreiro-Martins, Pedro Sci Prog Article Though the approach used to classify chronic respiratory diseases is changing to a treatable-traits (TT) approach, data regarding very elderly patients is lacking. The objectives of this study were to assess TT frequency in very elderly patients and to study the link between extrapulmonary TT and ventilatory defects. Individuals (≥75 years) residing in elderly care centres answered a standardised questionnaire, underwent spirometry, atopy and fractional exhaled nitric oxide assessments and had their blood pressure and peripheral pulse oximetry measured. Pulmonary, extrapulmonary and behavioural TT were evaluated. Outcome variables were an airflow limitation (post-bronchodilator z-score FEV(1)/FVC<−1.64) and a restrictive spirometry pattern (z-score FEV(1)/FVC ≥ +1.64 and z-score FVC<−1.64). Seventy-two percent of the individuals who took part in the study (n = 234) were women, and the median age of participants was 86 (IQR: 7.4). At least one pulmonary TT was identified in 105 (44.9%) individuals. The most frequent extrapulmonary TTs were: persistent systemic inflammation (47.0%), anaemia (34.4%), depression (32.5%) and obesity (27.4). Airflow limitation was exclusively associated with smoking (OR 5.03; 95% CI 1.56–16.22). A restrictive spirometry pattern was associated with cognitive impairment (OR: 3.89; 95% CI: 1.55–9.79). A high frequency of various TTs was found. The novel association between a restrictive spirometry pattern and cognitive impairment highlights the urgency of clinical research on this vulnerable age group. SAGE Publications 2021-04-30 /pmc/articles/PMC10305819/ /pubmed/33929910 http://dx.doi.org/10.1177/00368504211013171 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Article
Gaspar-Marques, João
Palmeiro, Teresa
Caires, Iolanda
Leiria Pinto, Paula
Neuparth, Nuno
Carreiro-Martins, Pedro
Ventilatory defects and treatable traits in very elderly patients
title Ventilatory defects and treatable traits in very elderly patients
title_full Ventilatory defects and treatable traits in very elderly patients
title_fullStr Ventilatory defects and treatable traits in very elderly patients
title_full_unstemmed Ventilatory defects and treatable traits in very elderly patients
title_short Ventilatory defects and treatable traits in very elderly patients
title_sort ventilatory defects and treatable traits in very elderly patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305819/
https://www.ncbi.nlm.nih.gov/pubmed/33929910
http://dx.doi.org/10.1177/00368504211013171
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