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Ventilatory defects and treatable traits in very elderly patients
Though the approach used to classify chronic respiratory diseases is changing to a treatable-traits (TT) approach, data regarding very elderly patients is lacking. The objectives of this study were to assess TT frequency in very elderly patients and to study the link between extrapulmonary TT and ve...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305819/ https://www.ncbi.nlm.nih.gov/pubmed/33929910 http://dx.doi.org/10.1177/00368504211013171 |
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author | Gaspar-Marques, João Palmeiro, Teresa Caires, Iolanda Leiria Pinto, Paula Neuparth, Nuno Carreiro-Martins, Pedro |
author_facet | Gaspar-Marques, João Palmeiro, Teresa Caires, Iolanda Leiria Pinto, Paula Neuparth, Nuno Carreiro-Martins, Pedro |
author_sort | Gaspar-Marques, João |
collection | PubMed |
description | Though the approach used to classify chronic respiratory diseases is changing to a treatable-traits (TT) approach, data regarding very elderly patients is lacking. The objectives of this study were to assess TT frequency in very elderly patients and to study the link between extrapulmonary TT and ventilatory defects. Individuals (≥75 years) residing in elderly care centres answered a standardised questionnaire, underwent spirometry, atopy and fractional exhaled nitric oxide assessments and had their blood pressure and peripheral pulse oximetry measured. Pulmonary, extrapulmonary and behavioural TT were evaluated. Outcome variables were an airflow limitation (post-bronchodilator z-score FEV(1)/FVC<−1.64) and a restrictive spirometry pattern (z-score FEV(1)/FVC ≥ +1.64 and z-score FVC<−1.64). Seventy-two percent of the individuals who took part in the study (n = 234) were women, and the median age of participants was 86 (IQR: 7.4). At least one pulmonary TT was identified in 105 (44.9%) individuals. The most frequent extrapulmonary TTs were: persistent systemic inflammation (47.0%), anaemia (34.4%), depression (32.5%) and obesity (27.4). Airflow limitation was exclusively associated with smoking (OR 5.03; 95% CI 1.56–16.22). A restrictive spirometry pattern was associated with cognitive impairment (OR: 3.89; 95% CI: 1.55–9.79). A high frequency of various TTs was found. The novel association between a restrictive spirometry pattern and cognitive impairment highlights the urgency of clinical research on this vulnerable age group. |
format | Online Article Text |
id | pubmed-10305819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-103058192023-08-09 Ventilatory defects and treatable traits in very elderly patients Gaspar-Marques, João Palmeiro, Teresa Caires, Iolanda Leiria Pinto, Paula Neuparth, Nuno Carreiro-Martins, Pedro Sci Prog Article Though the approach used to classify chronic respiratory diseases is changing to a treatable-traits (TT) approach, data regarding very elderly patients is lacking. The objectives of this study were to assess TT frequency in very elderly patients and to study the link between extrapulmonary TT and ventilatory defects. Individuals (≥75 years) residing in elderly care centres answered a standardised questionnaire, underwent spirometry, atopy and fractional exhaled nitric oxide assessments and had their blood pressure and peripheral pulse oximetry measured. Pulmonary, extrapulmonary and behavioural TT were evaluated. Outcome variables were an airflow limitation (post-bronchodilator z-score FEV(1)/FVC<−1.64) and a restrictive spirometry pattern (z-score FEV(1)/FVC ≥ +1.64 and z-score FVC<−1.64). Seventy-two percent of the individuals who took part in the study (n = 234) were women, and the median age of participants was 86 (IQR: 7.4). At least one pulmonary TT was identified in 105 (44.9%) individuals. The most frequent extrapulmonary TTs were: persistent systemic inflammation (47.0%), anaemia (34.4%), depression (32.5%) and obesity (27.4). Airflow limitation was exclusively associated with smoking (OR 5.03; 95% CI 1.56–16.22). A restrictive spirometry pattern was associated with cognitive impairment (OR: 3.89; 95% CI: 1.55–9.79). A high frequency of various TTs was found. The novel association between a restrictive spirometry pattern and cognitive impairment highlights the urgency of clinical research on this vulnerable age group. SAGE Publications 2021-04-30 /pmc/articles/PMC10305819/ /pubmed/33929910 http://dx.doi.org/10.1177/00368504211013171 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Article Gaspar-Marques, João Palmeiro, Teresa Caires, Iolanda Leiria Pinto, Paula Neuparth, Nuno Carreiro-Martins, Pedro Ventilatory defects and treatable traits in very elderly patients |
title | Ventilatory defects and treatable traits in very elderly
patients |
title_full | Ventilatory defects and treatable traits in very elderly
patients |
title_fullStr | Ventilatory defects and treatable traits in very elderly
patients |
title_full_unstemmed | Ventilatory defects and treatable traits in very elderly
patients |
title_short | Ventilatory defects and treatable traits in very elderly
patients |
title_sort | ventilatory defects and treatable traits in very elderly
patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305819/ https://www.ncbi.nlm.nih.gov/pubmed/33929910 http://dx.doi.org/10.1177/00368504211013171 |
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