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Stepwise evaluation for the risk of metabolic unhealthiness and significant non-alcoholic fatty liver disease in India

BACKGROUND: Non-communicable diseases including metabolic health disorders are becoming area of concern for low/middle income countries with poor health-care resources. Present study was planned to assess the prevalence of metabolically unhealthy (MU) subjects in the community and proportion of the...

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Autores principales: Mukherjee, Partha Sarathi, Ghosh, Sujoy, Mukhopadhyay, Pradip, Das, Dipesh Kumar, Sarkar, Pabak, Majumdar, Saibal, Chatterjee, Kajal, Chowdhury, Abhijit, Das, Kausik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306046/
https://www.ncbi.nlm.nih.gov/pubmed/37384057
http://dx.doi.org/10.1016/j.lansea.2023.100142
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author Mukherjee, Partha Sarathi
Ghosh, Sujoy
Mukhopadhyay, Pradip
Das, Dipesh Kumar
Sarkar, Pabak
Majumdar, Saibal
Chatterjee, Kajal
Chowdhury, Abhijit
Das, Kausik
author_facet Mukherjee, Partha Sarathi
Ghosh, Sujoy
Mukhopadhyay, Pradip
Das, Dipesh Kumar
Sarkar, Pabak
Majumdar, Saibal
Chatterjee, Kajal
Chowdhury, Abhijit
Das, Kausik
author_sort Mukherjee, Partha Sarathi
collection PubMed
description BACKGROUND: Non-communicable diseases including metabolic health disorders are becoming area of concern for low/middle income countries with poor health-care resources. Present study was planned to assess the prevalence of metabolically unhealthy (MU) subjects in the community and proportion of the MU subjects having the risk of significant Non-alcoholic Fatty Liver Disease (NAFLD) using a step-wise evaluation strategy in a resource-poor setting. METHODS: Study was performed in 19 community development blocks of Birbhum district, West Bengal, India. Every fifth member in the electoral list was included for the first step evaluation (n = 79,957/1,019,365, 7.8%) to detect any metabolic risk. Subjects with any metabolic risk in the first step (n = 9819/41,095, 24%) were taken for second step evaluation with Fasting blood glucose (FBG) and ALT. Subjects with elevated FBG and/or ALT in the second step (n = 1403/5283, 27%) were taken into third step evaluation. FINDING: At least one risk factor was found in 51.4% (n = 41,095/79,957). 63% (n = 885/1403) of the subjects with metabolic abnormality (third step) had MU state making its overall prevalence of 1.1% (n = 885/79,957). 53% of MU subjects (n = 470/885) had ‘persistently elevated ALT’ suggesting the risk of having significant NAFLD. INTERPRETATION: Step-wise evaluation strategy could detect the subjects at risk, actually having MU state and proportion of MU subjects at risk of having ‘persistently elevated ALT’ (surrogate of significant NAFLD) in the community with minimum utilization of scarce resources. FUNDING: This study was funded by 10.13039/100001009Bristol Myers Squibb Foundation, USA, under the program ‘Together on Diabetes Asia’ (Project Number: 1205 – LFWB).
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spelling pubmed-103060462023-06-28 Stepwise evaluation for the risk of metabolic unhealthiness and significant non-alcoholic fatty liver disease in India Mukherjee, Partha Sarathi Ghosh, Sujoy Mukhopadhyay, Pradip Das, Dipesh Kumar Sarkar, Pabak Majumdar, Saibal Chatterjee, Kajal Chowdhury, Abhijit Das, Kausik Lancet Reg Health Southeast Asia Articles BACKGROUND: Non-communicable diseases including metabolic health disorders are becoming area of concern for low/middle income countries with poor health-care resources. Present study was planned to assess the prevalence of metabolically unhealthy (MU) subjects in the community and proportion of the MU subjects having the risk of significant Non-alcoholic Fatty Liver Disease (NAFLD) using a step-wise evaluation strategy in a resource-poor setting. METHODS: Study was performed in 19 community development blocks of Birbhum district, West Bengal, India. Every fifth member in the electoral list was included for the first step evaluation (n = 79,957/1,019,365, 7.8%) to detect any metabolic risk. Subjects with any metabolic risk in the first step (n = 9819/41,095, 24%) were taken for second step evaluation with Fasting blood glucose (FBG) and ALT. Subjects with elevated FBG and/or ALT in the second step (n = 1403/5283, 27%) were taken into third step evaluation. FINDING: At least one risk factor was found in 51.4% (n = 41,095/79,957). 63% (n = 885/1403) of the subjects with metabolic abnormality (third step) had MU state making its overall prevalence of 1.1% (n = 885/79,957). 53% of MU subjects (n = 470/885) had ‘persistently elevated ALT’ suggesting the risk of having significant NAFLD. INTERPRETATION: Step-wise evaluation strategy could detect the subjects at risk, actually having MU state and proportion of MU subjects at risk of having ‘persistently elevated ALT’ (surrogate of significant NAFLD) in the community with minimum utilization of scarce resources. FUNDING: This study was funded by 10.13039/100001009Bristol Myers Squibb Foundation, USA, under the program ‘Together on Diabetes Asia’ (Project Number: 1205 – LFWB). Elsevier 2023-01-19 /pmc/articles/PMC10306046/ /pubmed/37384057 http://dx.doi.org/10.1016/j.lansea.2023.100142 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Articles
Mukherjee, Partha Sarathi
Ghosh, Sujoy
Mukhopadhyay, Pradip
Das, Dipesh Kumar
Sarkar, Pabak
Majumdar, Saibal
Chatterjee, Kajal
Chowdhury, Abhijit
Das, Kausik
Stepwise evaluation for the risk of metabolic unhealthiness and significant non-alcoholic fatty liver disease in India
title Stepwise evaluation for the risk of metabolic unhealthiness and significant non-alcoholic fatty liver disease in India
title_full Stepwise evaluation for the risk of metabolic unhealthiness and significant non-alcoholic fatty liver disease in India
title_fullStr Stepwise evaluation for the risk of metabolic unhealthiness and significant non-alcoholic fatty liver disease in India
title_full_unstemmed Stepwise evaluation for the risk of metabolic unhealthiness and significant non-alcoholic fatty liver disease in India
title_short Stepwise evaluation for the risk of metabolic unhealthiness and significant non-alcoholic fatty liver disease in India
title_sort stepwise evaluation for the risk of metabolic unhealthiness and significant non-alcoholic fatty liver disease in india
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306046/
https://www.ncbi.nlm.nih.gov/pubmed/37384057
http://dx.doi.org/10.1016/j.lansea.2023.100142
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