Sequence controlled secondary structure is important for the site-selectivity of lanthipeptide cyclization

Lanthipeptides are ribosomally synthesized and post-translationally modified peptides that are generated from precursor peptides through a dehydration and cyclization process. ProcM, a class II lanthipeptide synthetase, demonstrates high substrate tolerance. It is enigmatic that a single enzyme can...

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Detalles Bibliográficos
Autores principales: Mi, Xuenan, Desormeaux, Emily K., Le, Tung T., van der Donk, Wilfred A., Shukla, Diwakar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306099/
https://www.ncbi.nlm.nih.gov/pubmed/37389248
http://dx.doi.org/10.1039/d2sc06546k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306099/
https://www.ncbi.nlm.nih.gov/pubmed/37389248
http://dx.doi.org/10.1039/d2sc06546k

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