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Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations

The selective functionalization of alkanes has long been recognized as a prominent challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) processes enable the direct generation of reactive alkyl radicals from feedstock alkanes and have been successfully employed in industri...

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Detalles Bibliográficos
Autores principales: Chang, Liang, Wang, Shun, An, Qing, Liu, Linxuan, Wang, Hexiang, Li, Yubo, Feng, Kaixuan, Zuo, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306100/
https://www.ncbi.nlm.nih.gov/pubmed/37389263
http://dx.doi.org/10.1039/d3sc01118f
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author Chang, Liang
Wang, Shun
An, Qing
Liu, Linxuan
Wang, Hexiang
Li, Yubo
Feng, Kaixuan
Zuo, Zhiwei
author_facet Chang, Liang
Wang, Shun
An, Qing
Liu, Linxuan
Wang, Hexiang
Li, Yubo
Feng, Kaixuan
Zuo, Zhiwei
author_sort Chang, Liang
collection PubMed
description The selective functionalization of alkanes has long been recognized as a prominent challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) processes enable the direct generation of reactive alkyl radicals from feedstock alkanes and have been successfully employed in industrial applications such as the methane chlorination process, etc. Nevertheless, challenges in the regulation of radical generation and reaction pathways have created substantial obstacles in the development of diversified alkane functionalizations. In recent years, the application of photoredox catalysis has provided exciting opportunities for alkane C–H functionalization under extremely mild conditions to trigger HAT processes and achieve radical-mediated functionalizations in a more selective manner. Considerable efforts have been devoted to building more efficient and cost-effective photocatalytic systems for sustainable transformations. In this perspective, we highlight the recent development of photocatalytic systems and provide our views on current challenges and future opportunities in this field.
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spelling pubmed-103061002023-06-29 Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations Chang, Liang Wang, Shun An, Qing Liu, Linxuan Wang, Hexiang Li, Yubo Feng, Kaixuan Zuo, Zhiwei Chem Sci Chemistry The selective functionalization of alkanes has long been recognized as a prominent challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) processes enable the direct generation of reactive alkyl radicals from feedstock alkanes and have been successfully employed in industrial applications such as the methane chlorination process, etc. Nevertheless, challenges in the regulation of radical generation and reaction pathways have created substantial obstacles in the development of diversified alkane functionalizations. In recent years, the application of photoredox catalysis has provided exciting opportunities for alkane C–H functionalization under extremely mild conditions to trigger HAT processes and achieve radical-mediated functionalizations in a more selective manner. Considerable efforts have been devoted to building more efficient and cost-effective photocatalytic systems for sustainable transformations. In this perspective, we highlight the recent development of photocatalytic systems and provide our views on current challenges and future opportunities in this field. The Royal Society of Chemistry 2023-05-22 /pmc/articles/PMC10306100/ /pubmed/37389263 http://dx.doi.org/10.1039/d3sc01118f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Chang, Liang
Wang, Shun
An, Qing
Liu, Linxuan
Wang, Hexiang
Li, Yubo
Feng, Kaixuan
Zuo, Zhiwei
Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations
title Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations
title_full Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations
title_fullStr Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations
title_full_unstemmed Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations
title_short Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations
title_sort resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306100/
https://www.ncbi.nlm.nih.gov/pubmed/37389263
http://dx.doi.org/10.1039/d3sc01118f
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