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Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations
The selective functionalization of alkanes has long been recognized as a prominent challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) processes enable the direct generation of reactive alkyl radicals from feedstock alkanes and have been successfully employed in industri...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306100/ https://www.ncbi.nlm.nih.gov/pubmed/37389263 http://dx.doi.org/10.1039/d3sc01118f |
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author | Chang, Liang Wang, Shun An, Qing Liu, Linxuan Wang, Hexiang Li, Yubo Feng, Kaixuan Zuo, Zhiwei |
author_facet | Chang, Liang Wang, Shun An, Qing Liu, Linxuan Wang, Hexiang Li, Yubo Feng, Kaixuan Zuo, Zhiwei |
author_sort | Chang, Liang |
collection | PubMed |
description | The selective functionalization of alkanes has long been recognized as a prominent challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) processes enable the direct generation of reactive alkyl radicals from feedstock alkanes and have been successfully employed in industrial applications such as the methane chlorination process, etc. Nevertheless, challenges in the regulation of radical generation and reaction pathways have created substantial obstacles in the development of diversified alkane functionalizations. In recent years, the application of photoredox catalysis has provided exciting opportunities for alkane C–H functionalization under extremely mild conditions to trigger HAT processes and achieve radical-mediated functionalizations in a more selective manner. Considerable efforts have been devoted to building more efficient and cost-effective photocatalytic systems for sustainable transformations. In this perspective, we highlight the recent development of photocatalytic systems and provide our views on current challenges and future opportunities in this field. |
format | Online Article Text |
id | pubmed-10306100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-103061002023-06-29 Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations Chang, Liang Wang, Shun An, Qing Liu, Linxuan Wang, Hexiang Li, Yubo Feng, Kaixuan Zuo, Zhiwei Chem Sci Chemistry The selective functionalization of alkanes has long been recognized as a prominent challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) processes enable the direct generation of reactive alkyl radicals from feedstock alkanes and have been successfully employed in industrial applications such as the methane chlorination process, etc. Nevertheless, challenges in the regulation of radical generation and reaction pathways have created substantial obstacles in the development of diversified alkane functionalizations. In recent years, the application of photoredox catalysis has provided exciting opportunities for alkane C–H functionalization under extremely mild conditions to trigger HAT processes and achieve radical-mediated functionalizations in a more selective manner. Considerable efforts have been devoted to building more efficient and cost-effective photocatalytic systems for sustainable transformations. In this perspective, we highlight the recent development of photocatalytic systems and provide our views on current challenges and future opportunities in this field. The Royal Society of Chemistry 2023-05-22 /pmc/articles/PMC10306100/ /pubmed/37389263 http://dx.doi.org/10.1039/d3sc01118f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Chang, Liang Wang, Shun An, Qing Liu, Linxuan Wang, Hexiang Li, Yubo Feng, Kaixuan Zuo, Zhiwei Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations |
title | Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations |
title_full | Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations |
title_fullStr | Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations |
title_full_unstemmed | Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations |
title_short | Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations |
title_sort | resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306100/ https://www.ncbi.nlm.nih.gov/pubmed/37389263 http://dx.doi.org/10.1039/d3sc01118f |
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