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Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice

Human CD34(+) hematopoietic stem and progenitor cells (HSPCs) are a standard source of cells for clinical HSC transplantations as well as experimental xenotransplantation to generate “humanized mice”. To further extend the range of applications of these humanized mice, we developed a protocol to eff...

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Detalles Bibliográficos
Autores principales:	Kuppers, Daniel A., Linton, Jonathan, Ortiz Espinosa, Sergio, McKenna, Kelly M., Rongvaux, Anthony, Paddison, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Lab Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306193/ https://www.ncbi.nlm.nih.gov/pubmed/37379309 http://dx.doi.org/10.1371/journal.pone.0287052

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