Human PBMC scRNA-seq–based aging clocks reveal ribosome to inflammation balance as a single-cell aging hallmark and super longevity

Quantifying aging rate is important for evaluating age-associated decline and mortality. A blood single-cell RNA sequencing dataset for seven supercentenarians (SCs) was recently generated. Here, we generate a reference 28-sample aging cohort to compute a single-cell level aging clock and to determi...

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Detalles Bibliográficos
Autores principales: Zhu, Hongming, Chen, Jiawei, Liu, Kangping, Gao, Lei, Wu, Haiyan, Ma, Liangliang, Zhou, Jieru, Liu, Zhongmin, Han, Jing-Dong J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306289/
https://www.ncbi.nlm.nih.gov/pubmed/37379396
http://dx.doi.org/10.1126/sciadv.abq7599

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