Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions

Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes. High resolution peripheral quantitative computed tomography (HR-pQCT) enables in vivo microstructure characterization but is limited in its ability to visualize important biologi...

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Autores principales: Garita, Barbara, Maligro, Jenna, Sadoughi, Saghi, Wu, Po Hung, Liebenberg, Ellen, Horvai, Andrew, Link, Thomas M., Kazakia, Galateia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306320/
https://www.ncbi.nlm.nih.gov/pubmed/37383338
http://dx.doi.org/10.1016/j.medntd.2021.100062
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author Garita, Barbara
Maligro, Jenna
Sadoughi, Saghi
Wu, Po Hung
Liebenberg, Ellen
Horvai, Andrew
Link, Thomas M.
Kazakia, Galateia J.
author_facet Garita, Barbara
Maligro, Jenna
Sadoughi, Saghi
Wu, Po Hung
Liebenberg, Ellen
Horvai, Andrew
Link, Thomas M.
Kazakia, Galateia J.
author_sort Garita, Barbara
collection PubMed
description Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes. High resolution peripheral quantitative computed tomography (HR-pQCT) enables in vivo microstructure characterization but is limited in its ability to visualize important biological features. We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D). Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility. These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation.
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spelling pubmed-103063202023-06-28 Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions Garita, Barbara Maligro, Jenna Sadoughi, Saghi Wu, Po Hung Liebenberg, Ellen Horvai, Andrew Link, Thomas M. Kazakia, Galateia J. Med Nov Technol Devices Article Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes. High resolution peripheral quantitative computed tomography (HR-pQCT) enables in vivo microstructure characterization but is limited in its ability to visualize important biological features. We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D). Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility. These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation. 2021-06 2021-02-03 /pmc/articles/PMC10306320/ /pubmed/37383338 http://dx.doi.org/10.1016/j.medntd.2021.100062 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Garita, Barbara
Maligro, Jenna
Sadoughi, Saghi
Wu, Po Hung
Liebenberg, Ellen
Horvai, Andrew
Link, Thomas M.
Kazakia, Galateia J.
Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions
title Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions
title_full Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions
title_fullStr Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions
title_full_unstemmed Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions
title_short Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions
title_sort microstructural abnormalities are evident by histology but not hr-pqct at the periosteal cortex of the human tibia under cvd and t2d conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306320/
https://www.ncbi.nlm.nih.gov/pubmed/37383338
http://dx.doi.org/10.1016/j.medntd.2021.100062
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