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Associations between cognitive impairment and computed tomography perfusion in different lobes in acute stroke of the anterior circulation
Background Cognitive impairment (CI) during the acute phase of stroke should not be ignored. The present study analyzed the relationship between computed tomography perfusion (CTP) in different lobes and CI during the acute phase of stroke in patients with cerebral infarction. Methods The present...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307000/ https://www.ncbi.nlm.nih.gov/pubmed/37379864 http://dx.doi.org/10.1055/s-0043-1768663 |
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author | Chu, Mengna Dong, Bin Huang, Chao |
author_facet | Chu, Mengna Dong, Bin Huang, Chao |
author_sort | Chu, Mengna |
collection | PubMed |
description | Background Cognitive impairment (CI) during the acute phase of stroke should not be ignored. The present study analyzed the relationship between computed tomography perfusion (CTP) in different lobes and CI during the acute phase of stroke in patients with cerebral infarction. Methods The present study included 125 subjects: 96 in the acute phase of stroke and 29 elderly healthy subjects as a control group. The Montreal Cognitive Assessment (MoCA) was used to evaluate the cognitive status of the two groups. The CTP scans include four parameters: cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT). Results The MoCA scores for naming, language and delayed recall significantly decreased only in patients with left cerebral infarctions. The MTT of the left vessels in the occipital lobe and the CBF of the right vessels in the frontal lobe were negatively related to the MoCA scores of patients with left infarction. The CBV of the left vessels in the frontal lobe and the CBF of left vessels in the parietal lobe were positively linked to the MoCA scores of patients with left infarction. The CBF of the right vessels in the temporal lobe was positively related to the MoCA scores of patients with right infarction. Finally, the CBF of the left vessels in the temporal lobe was inversely correlated with the MoCA scores of patients with right infarctions. Conclusion During the acute phase of stroke, CTP was closely associated with CI. Changed CTP could be a potential neuroimaging biomarker to predict CI during the acute phase of stroke. |
format | Online Article Text |
id | pubmed-10307000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Thieme Revinter Publicações Ltda. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103070002023-06-29 Associations between cognitive impairment and computed tomography perfusion in different lobes in acute stroke of the anterior circulation Chu, Mengna Dong, Bin Huang, Chao Arq Neuropsiquiatr Background Cognitive impairment (CI) during the acute phase of stroke should not be ignored. The present study analyzed the relationship between computed tomography perfusion (CTP) in different lobes and CI during the acute phase of stroke in patients with cerebral infarction. Methods The present study included 125 subjects: 96 in the acute phase of stroke and 29 elderly healthy subjects as a control group. The Montreal Cognitive Assessment (MoCA) was used to evaluate the cognitive status of the two groups. The CTP scans include four parameters: cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT). Results The MoCA scores for naming, language and delayed recall significantly decreased only in patients with left cerebral infarctions. The MTT of the left vessels in the occipital lobe and the CBF of the right vessels in the frontal lobe were negatively related to the MoCA scores of patients with left infarction. The CBV of the left vessels in the frontal lobe and the CBF of left vessels in the parietal lobe were positively linked to the MoCA scores of patients with left infarction. The CBF of the right vessels in the temporal lobe was positively related to the MoCA scores of patients with right infarction. Finally, the CBF of the left vessels in the temporal lobe was inversely correlated with the MoCA scores of patients with right infarctions. Conclusion During the acute phase of stroke, CTP was closely associated with CI. Changed CTP could be a potential neuroimaging biomarker to predict CI during the acute phase of stroke. Thieme Revinter Publicações Ltda. 2023-06-28 /pmc/articles/PMC10307000/ /pubmed/37379864 http://dx.doi.org/10.1055/s-0043-1768663 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Chu, Mengna Dong, Bin Huang, Chao Associations between cognitive impairment and computed tomography perfusion in different lobes in acute stroke of the anterior circulation |
title | Associations between cognitive impairment and computed tomography perfusion in different lobes in acute stroke of the anterior circulation |
title_full | Associations between cognitive impairment and computed tomography perfusion in different lobes in acute stroke of the anterior circulation |
title_fullStr | Associations between cognitive impairment and computed tomography perfusion in different lobes in acute stroke of the anterior circulation |
title_full_unstemmed | Associations between cognitive impairment and computed tomography perfusion in different lobes in acute stroke of the anterior circulation |
title_short | Associations between cognitive impairment and computed tomography perfusion in different lobes in acute stroke of the anterior circulation |
title_sort | associations between cognitive impairment and computed tomography perfusion in different lobes in acute stroke of the anterior circulation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307000/ https://www.ncbi.nlm.nih.gov/pubmed/37379864 http://dx.doi.org/10.1055/s-0043-1768663 |
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