Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging

The magnitude and quality of the germinal center (GC) response decline with age, resulting in poor vaccine-induced immunity in older individuals. A functional GC requires the co-ordination of multiple cell types across time and space, in particular across its two functionally distinct compartments:...

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Detalles Bibliográficos
Autores principales: Silva-Cayetano, Alyssa, Fra-Bido, Sigrid, Robert, Philippe A., Innocentin, Silvia, Burton, Alice R., Watson, Emily M., Lee, Jia Le, Webb, Louise M. C., Foster, William S., McKenzie, Ross C. J., Bignon, Alexandre, Vanderleyden, Ine, Alterauge, Dominik, Lemos, Julia P., Carr, Edward J., Hill, Danika L., Cinti, Isabella, Balabanian, Karl, Baumjohann, Dirk, Espeli, Marion, Meyer-Hermann, Michael, Denton, Alice E., Linterman, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307630/
https://www.ncbi.nlm.nih.gov/pubmed/37217705
http://dx.doi.org/10.1038/s41590-023-01519-9

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