SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity

Spalt-like transcription factor 1 (SALL1) is a critical regulator of organogenesis and microglia identity. Here we demonstrate that disruption of a conserved microglia-specific super-enhancer interacting with the Sall1 promoter results in complete and specific loss of Sall1 expression in microglia....

Descripción completa

Detalles Bibliográficos
Autores principales: Fixsen, Bethany R., Han, Claudia Z., Zhou, Yi, Spann, Nathanael J., Saisan, Payam, Shen, Zeyang, Balak, Christopher, Sakai, Mashito, Cobo, Isidoro, Holtman, Inge R., Warden, Anna S., Ramirez, Gabriela, Collier, Jana G., Pasillas, Martina P., Yu, Miao, Hu, Rong, Li, Bin, Belhocine, Sarah, Gosselin, David, Coufal, Nicole G., Ren, Bing, Glass, Christopher K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307637/
https://www.ncbi.nlm.nih.gov/pubmed/37322178
http://dx.doi.org/10.1038/s41590-023-01528-8

Ejemplares similares

Ejemplares similares