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New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics

Irritable bowel syndrome (IBS) is a complex multifactorial condition including alterations of the gut–brain axis, intestinal permeability, mucosal neuro-immune interactions, and microbiota imbalance. Recent advances proposed epigenetic factors as possible regulators of several mechanisms involved in...

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Autores principales: Dothel, Giovanni, Barbaro, Maria Raffaella, Di Vito, Aldo, Ravegnini, Gloria, Gorini, Francesca, Monesmith, Sarah, Coschina, Emma, Benuzzi, Eva, Fuschi, Daniele, Palombo, Marta, Bonomini, Francesca, Morroni, Fabiana, Hrelia, Patrizia, Barbara, Giovanni, Angelini, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307698/
https://www.ncbi.nlm.nih.gov/pubmed/37160449
http://dx.doi.org/10.1007/s00535-023-01997-6
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author Dothel, Giovanni
Barbaro, Maria Raffaella
Di Vito, Aldo
Ravegnini, Gloria
Gorini, Francesca
Monesmith, Sarah
Coschina, Emma
Benuzzi, Eva
Fuschi, Daniele
Palombo, Marta
Bonomini, Francesca
Morroni, Fabiana
Hrelia, Patrizia
Barbara, Giovanni
Angelini, Sabrina
author_facet Dothel, Giovanni
Barbaro, Maria Raffaella
Di Vito, Aldo
Ravegnini, Gloria
Gorini, Francesca
Monesmith, Sarah
Coschina, Emma
Benuzzi, Eva
Fuschi, Daniele
Palombo, Marta
Bonomini, Francesca
Morroni, Fabiana
Hrelia, Patrizia
Barbara, Giovanni
Angelini, Sabrina
author_sort Dothel, Giovanni
collection PubMed
description Irritable bowel syndrome (IBS) is a complex multifactorial condition including alterations of the gut–brain axis, intestinal permeability, mucosal neuro-immune interactions, and microbiota imbalance. Recent advances proposed epigenetic factors as possible regulators of several mechanisms involved in IBS pathophysiology. These epigenetic factors include biomolecular mechanisms inducing chromosome-related and heritable changes in gene expression regardless of DNA coding sequence. Accordingly, altered gut microbiota may increase the production of metabolites such as sodium butyrate, a prominent inhibitor of histone deacetylases. Patients with IBS showed an increased amount of butyrate-producing microbial phila as well as an altered profile of methylated genes and micro-RNAs (miRNAs). Importantly, gene acetylation as well as specific miRNA profiles are involved in different IBS mechanisms and may be applied for future diagnostic purposes, especially to detect increased gut permeability and visceromotor dysfunctions. In this review, we summarize current knowledge of the role of epigenetics in IBS pathophysiology.
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spelling pubmed-103076982023-06-30 New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics Dothel, Giovanni Barbaro, Maria Raffaella Di Vito, Aldo Ravegnini, Gloria Gorini, Francesca Monesmith, Sarah Coschina, Emma Benuzzi, Eva Fuschi, Daniele Palombo, Marta Bonomini, Francesca Morroni, Fabiana Hrelia, Patrizia Barbara, Giovanni Angelini, Sabrina J Gastroenterol Review Irritable bowel syndrome (IBS) is a complex multifactorial condition including alterations of the gut–brain axis, intestinal permeability, mucosal neuro-immune interactions, and microbiota imbalance. Recent advances proposed epigenetic factors as possible regulators of several mechanisms involved in IBS pathophysiology. These epigenetic factors include biomolecular mechanisms inducing chromosome-related and heritable changes in gene expression regardless of DNA coding sequence. Accordingly, altered gut microbiota may increase the production of metabolites such as sodium butyrate, a prominent inhibitor of histone deacetylases. Patients with IBS showed an increased amount of butyrate-producing microbial phila as well as an altered profile of methylated genes and micro-RNAs (miRNAs). Importantly, gene acetylation as well as specific miRNA profiles are involved in different IBS mechanisms and may be applied for future diagnostic purposes, especially to detect increased gut permeability and visceromotor dysfunctions. In this review, we summarize current knowledge of the role of epigenetics in IBS pathophysiology. Springer Nature Singapore 2023-05-09 2023 /pmc/articles/PMC10307698/ /pubmed/37160449 http://dx.doi.org/10.1007/s00535-023-01997-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Dothel, Giovanni
Barbaro, Maria Raffaella
Di Vito, Aldo
Ravegnini, Gloria
Gorini, Francesca
Monesmith, Sarah
Coschina, Emma
Benuzzi, Eva
Fuschi, Daniele
Palombo, Marta
Bonomini, Francesca
Morroni, Fabiana
Hrelia, Patrizia
Barbara, Giovanni
Angelini, Sabrina
New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics
title New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics
title_full New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics
title_fullStr New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics
title_full_unstemmed New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics
title_short New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics
title_sort new insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307698/
https://www.ncbi.nlm.nih.gov/pubmed/37160449
http://dx.doi.org/10.1007/s00535-023-01997-6
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