The Current Clinical Trial Landscape for Hidradenitis Suppurativa: A Narrative Review

Hidradenitis suppurativa (HS) is a skin disease resulting from chronic, recurrent inflammation around hair follicles, characterized by proinflammatory cytokines such as IL-1, IL-17, IL-23, and TNF-α. While adalimumab, a TNF-α targeting human IgG monoclonal antibody, is the only approved treatment fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Hunt, Amanda, Qian, Victoria, Olds, Hailey, Daveluy, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307738/
https://www.ncbi.nlm.nih.gov/pubmed/37261652
http://dx.doi.org/10.1007/s13555-023-00935-x
_version_ 1785066099741556736
author Hunt, Amanda
Qian, Victoria
Olds, Hailey
Daveluy, Steven
author_facet Hunt, Amanda
Qian, Victoria
Olds, Hailey
Daveluy, Steven
author_sort Hunt, Amanda
collection PubMed
description Hidradenitis suppurativa (HS) is a skin disease resulting from chronic, recurrent inflammation around hair follicles, characterized by proinflammatory cytokines such as IL-1, IL-17, IL-23, and TNF-α. While adalimumab, a TNF-α targeting human IgG monoclonal antibody, is the only approved treatment for HS, there are many other therapies being investigated now targeting other key players in inflammatory pathways such as the cytokines listed above, C5a in the complement pathway, and Janus kinase (JAK). This review discusses current clinical trials for biologics and small molecules, procedures, and wound dressings undergoing study in hidradenitis suppurativa.
format Online
Article
Text
id pubmed-10307738
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Healthcare
record_format MEDLINE/PubMed
spelling pubmed-103077382023-06-30 The Current Clinical Trial Landscape for Hidradenitis Suppurativa: A Narrative Review Hunt, Amanda Qian, Victoria Olds, Hailey Daveluy, Steven Dermatol Ther (Heidelb) Review Hidradenitis suppurativa (HS) is a skin disease resulting from chronic, recurrent inflammation around hair follicles, characterized by proinflammatory cytokines such as IL-1, IL-17, IL-23, and TNF-α. While adalimumab, a TNF-α targeting human IgG monoclonal antibody, is the only approved treatment for HS, there are many other therapies being investigated now targeting other key players in inflammatory pathways such as the cytokines listed above, C5a in the complement pathway, and Janus kinase (JAK). This review discusses current clinical trials for biologics and small molecules, procedures, and wound dressings undergoing study in hidradenitis suppurativa. Springer Healthcare 2023-06-01 /pmc/articles/PMC10307738/ /pubmed/37261652 http://dx.doi.org/10.1007/s13555-023-00935-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Hunt, Amanda
Qian, Victoria
Olds, Hailey
Daveluy, Steven
The Current Clinical Trial Landscape for Hidradenitis Suppurativa: A Narrative Review
title The Current Clinical Trial Landscape for Hidradenitis Suppurativa: A Narrative Review
title_full The Current Clinical Trial Landscape for Hidradenitis Suppurativa: A Narrative Review
title_fullStr The Current Clinical Trial Landscape for Hidradenitis Suppurativa: A Narrative Review
title_full_unstemmed The Current Clinical Trial Landscape for Hidradenitis Suppurativa: A Narrative Review
title_short The Current Clinical Trial Landscape for Hidradenitis Suppurativa: A Narrative Review
title_sort current clinical trial landscape for hidradenitis suppurativa: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307738/
https://www.ncbi.nlm.nih.gov/pubmed/37261652
http://dx.doi.org/10.1007/s13555-023-00935-x
work_keys_str_mv AT huntamanda thecurrentclinicaltriallandscapeforhidradenitissuppurativaanarrativereview
AT qianvictoria thecurrentclinicaltriallandscapeforhidradenitissuppurativaanarrativereview
AT oldshailey thecurrentclinicaltriallandscapeforhidradenitissuppurativaanarrativereview
AT daveluysteven thecurrentclinicaltriallandscapeforhidradenitissuppurativaanarrativereview
AT huntamanda currentclinicaltriallandscapeforhidradenitissuppurativaanarrativereview
AT qianvictoria currentclinicaltriallandscapeforhidradenitissuppurativaanarrativereview
AT oldshailey currentclinicaltriallandscapeforhidradenitissuppurativaanarrativereview
AT daveluysteven currentclinicaltriallandscapeforhidradenitissuppurativaanarrativereview

Ejemplares similares