USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer

SREBP2 is a master regulator of the mevalonate pathway (MVP), a biosynthetic process that drives the synthesis of dolichol, heme A, ubiquinone and cholesterol and also provides substrates for protein prenylation. Here, we identify SREBP2 as a novel substrate for USP28, a deubiquitinating enzyme that...

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Detalles Bibliográficos
Autores principales: Maier, Carina R., Hartmann, Oliver, Prieto-Garcia, Cristian, Al-Shami, Kamal M., Schlicker, Lisa, Vogel, Felix C. E., Haid, Silke, Klann, Kevin, Buck, Viktoria, Münch, Christian, Schmitz, Werner, Einig, Elias, Krenz, Bastian, Calzado, Marco A., Eilers, Martin, Popov, Nikita, Rosenfeldt, Mathias T., Diefenbacher, Markus E., Schulze, Almut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307777/
https://www.ncbi.nlm.nih.gov/pubmed/37202505
http://dx.doi.org/10.1038/s41418-023-01173-6

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