Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET

Drug repurposing is a versatile strategy to improve current therapies. Disulfiram has long been used in the treatment of alcohol dependency and multiple clinical trials to evaluate its clinical value in oncology are ongoing. We have recently reported that the disulfiram metabolite diethyldithiocarba...

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Detalles Bibliográficos
Autores principales: Kanellis, Dimitris C., Zisi, Asimina, Skrott, Zdenek, Lemmens, Bennie, Espinoza, Jaime A., Kosar, Martin, Björkman, Andrea, Li, Xuexin, Arampatzis, Stefanos, Bartkova, Jirina, Andújar-Sánchez, Miguel, Fernandez-Capetillo, Oscar, Mistrik, Martin, Lindström, Mikael S., Bartek, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307793/
https://www.ncbi.nlm.nih.gov/pubmed/37142656
http://dx.doi.org/10.1038/s41418-023-01167-4

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