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Gene-specific machine learning for pathogenicity prediction of rare BRCA1 and BRCA2 missense variants
Machine learning-based pathogenicity prediction helps interpret rare missense variants of BRCA1 and BRCA2, which are associated with hereditary cancers. Recent studies have shown that classifiers trained using variants of a specific gene or a set of genes related to a particular disease perform bett...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307865/ https://www.ncbi.nlm.nih.gov/pubmed/37380723 http://dx.doi.org/10.1038/s41598-023-37698-6 |