Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy

Hyperactivated ribosome biosynthesis is attributed to a need for elevated protein synthesis that accommodates cell growth and division, and is characterized by nucleomorphometric alterations and increased nucleolar counts. Ribosome biogenesis is challenged when DNA-damaging treatments such as radiot...

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Detalles Bibliográficos
Autores principales: Metge, Brandon J., Alsheikh, Heba A., Chen, Dongquan, Elhamamsy, Amr R., Hinshaw, Dominique C., Chen, Bo-Ruei, Sleckman, Barry P., Samant, Rajeev S., Shevde, Lalita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307872/
https://www.ncbi.nlm.nih.gov/pubmed/37380890
http://dx.doi.org/10.1038/s41698-023-00410-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307872/
https://www.ncbi.nlm.nih.gov/pubmed/37380890
http://dx.doi.org/10.1038/s41698-023-00410-y

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