p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer

Oncogenic KRAS activation, inflammation and p53 mutation are key drivers of pancreatic cancer (PC) development. Here we report iASPP, an inhibitor of p53, as a paradoxical suppressor of inflammation and oncogenic KRAS(G12D)-driven PC tumorigenesis. iASPP suppresses PC onset driven by KRAS(G12D) alon...

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Detalles Bibliográficos
Autores principales: Miller, Paul, Akama-Garren, Elliot H., Owen, Richard P., Demetriou, Constantinos, Carroll, Thomas M., Slee, Elizabeth, Al Moussawi, Khatoun, Ellis, Michael, Goldin, Robert, O’Neill, Eric, Lu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307949/
https://www.ncbi.nlm.nih.gov/pubmed/37270580
http://dx.doi.org/10.1038/s41418-023-01168-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307949/
https://www.ncbi.nlm.nih.gov/pubmed/37270580
http://dx.doi.org/10.1038/s41418-023-01168-3

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