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Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective

Due to excess energy intake and a sedentary lifestyle, the prevalence of obesity is rising steadily and has emerged as a global public health problem. Adipose tissue undergoes structural remodeling and dysfunction in the obese state. Secreted proteins derived from the liver, also termed as hepatokin...

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Detalles Bibliográficos
Autores principales: Zhang, Yao, Wang, Yibing, Liu, Junli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308077/
https://www.ncbi.nlm.nih.gov/pubmed/37396511
http://dx.doi.org/10.1016/j.gendis.2021.12.011
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author Zhang, Yao
Wang, Yibing
Liu, Junli
author_facet Zhang, Yao
Wang, Yibing
Liu, Junli
author_sort Zhang, Yao
collection PubMed
description Due to excess energy intake and a sedentary lifestyle, the prevalence of obesity is rising steadily and has emerged as a global public health problem. Adipose tissue undergoes structural remodeling and dysfunction in the obese state. Secreted proteins derived from the liver, also termed as hepatokines, exert multiple effects on adipose tissue remodeling and the development of obesity, and has drawn extensive attention for their therapeutic potential in the treatment of obesity and related diseases. Several novel hepatokines and their functions on systemic metabolism have been interrogated recently as well. The drug development programs targeting hepatokines also have shown inspiring benefits in obesity treatment. In this review, we outline how adipose tissue changes during obesity. Then, we summarize and critically analyze the novel findings on the effects of metabolic “beneficial” and metabolic “harmful” hepatokines to adipose tissue. We also discuss the in-depth molecular mechanism that hepatokines may mediate the liver-adipose tissue crosstalk, the novel technologies targeting hepatokines and their receptors in vivo to explore their functions, and the potential application of these interventions in clinical practice.
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spelling pubmed-103080772023-06-30 Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective Zhang, Yao Wang, Yibing Liu, Junli Genes Dis Review Article Due to excess energy intake and a sedentary lifestyle, the prevalence of obesity is rising steadily and has emerged as a global public health problem. Adipose tissue undergoes structural remodeling and dysfunction in the obese state. Secreted proteins derived from the liver, also termed as hepatokines, exert multiple effects on adipose tissue remodeling and the development of obesity, and has drawn extensive attention for their therapeutic potential in the treatment of obesity and related diseases. Several novel hepatokines and their functions on systemic metabolism have been interrogated recently as well. The drug development programs targeting hepatokines also have shown inspiring benefits in obesity treatment. In this review, we outline how adipose tissue changes during obesity. Then, we summarize and critically analyze the novel findings on the effects of metabolic “beneficial” and metabolic “harmful” hepatokines to adipose tissue. We also discuss the in-depth molecular mechanism that hepatokines may mediate the liver-adipose tissue crosstalk, the novel technologies targeting hepatokines and their receptors in vivo to explore their functions, and the potential application of these interventions in clinical practice. Chongqing Medical University 2022-02-02 /pmc/articles/PMC10308077/ /pubmed/37396511 http://dx.doi.org/10.1016/j.gendis.2021.12.011 Text en © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Zhang, Yao
Wang, Yibing
Liu, Junli
Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
title Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
title_full Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
title_fullStr Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
title_full_unstemmed Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
title_short Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
title_sort friend or foe for obesity: how hepatokines remodel adipose tissues and translational perspective
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308077/
https://www.ncbi.nlm.nih.gov/pubmed/37396511
http://dx.doi.org/10.1016/j.gendis.2021.12.011
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