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Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method

Introduction: Usnic acid (UA) and barbatic acid (BA), two typical dibenzofurans and depsides in lichen, have a wide range of pharmacological activities and hepatotoxicity concerns. This study aimed to clarify the metabolic pathway of UA and BA and illuminate the relationship between metabolism and t...

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Detalles Bibliográficos
Autores principales:	Wang, Hanxue, Xuan, Min, Diao, Juanjuan, Xu, Nan, Li, Manlin, Huang, Cheng, Wang, Changhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308081/ https://www.ncbi.nlm.nih.gov/pubmed/37397492 http://dx.doi.org/10.3389/fphar.2023.1207928

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