Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies

Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth. This study reviewed the biological properties of NK cells, the dynamic ph...

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Detalles Bibliográficos
Autores principales: Wang, Liping, Chen, Zhe, Liu, Guohong, Pan, Yunbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308134/
https://www.ncbi.nlm.nih.gov/pubmed/37396514
http://dx.doi.org/10.1016/j.gendis.2022.07.009
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author Wang, Liping
Chen, Zhe
Liu, Guohong
Pan, Yunbao
author_facet Wang, Liping
Chen, Zhe
Liu, Guohong
Pan, Yunbao
author_sort Wang, Liping
collection PubMed
description Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth. This study reviewed the biological properties of NK cells, the dynamic phenotypic changes of NK cells in the TME, and the communication between NK cells and other immune and nonimmune cells.
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spelling pubmed-103081342023-06-30 Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies Wang, Liping Chen, Zhe Liu, Guohong Pan, Yunbao Genes Dis Review Article Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth. This study reviewed the biological properties of NK cells, the dynamic phenotypic changes of NK cells in the TME, and the communication between NK cells and other immune and nonimmune cells. Chongqing Medical University 2022-08-06 /pmc/articles/PMC10308134/ /pubmed/37396514 http://dx.doi.org/10.1016/j.gendis.2022.07.009 Text en © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Wang, Liping
Chen, Zhe
Liu, Guohong
Pan, Yunbao
Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies
title Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies
title_full Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies
title_fullStr Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies
title_full_unstemmed Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies
title_short Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies
title_sort functional crosstalk and regulation of natural killer cells in tumor microenvironment: significance and potential therapeutic strategies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308134/
https://www.ncbi.nlm.nih.gov/pubmed/37396514
http://dx.doi.org/10.1016/j.gendis.2022.07.009
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