The glymphatic system: a new perspective on brain diseases

The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the endfeet of astrocytes, which can deliver nutrients and active substances to the brain parenchyma through periarterial cerebrospinal fluid (CSF) influx pathway and remove metabolic wastes through perivenous cleara...

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Detalles Bibliográficos
Autores principales: Ding, Zhao, Fan, Xiaodi, Zhang, Yehao, Yao, Mingjiang, Wang, Guangrui, Dong, Yilei, Liu, Jianxun, Song, Wenting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308198/
https://www.ncbi.nlm.nih.gov/pubmed/37396658
http://dx.doi.org/10.3389/fnagi.2023.1179988
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author Ding, Zhao
Fan, Xiaodi
Zhang, Yehao
Yao, Mingjiang
Wang, Guangrui
Dong, Yilei
Liu, Jianxun
Song, Wenting
author_facet Ding, Zhao
Fan, Xiaodi
Zhang, Yehao
Yao, Mingjiang
Wang, Guangrui
Dong, Yilei
Liu, Jianxun
Song, Wenting
author_sort Ding, Zhao
collection PubMed
description The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the endfeet of astrocytes, which can deliver nutrients and active substances to the brain parenchyma through periarterial cerebrospinal fluid (CSF) influx pathway and remove metabolic wastes through perivenous clearance routes. This paper summarizes the composition, overall fluid flow, solute transport, related diseases, affecting factors, and preclinical research methods of the glymphatic system. In doing so, we aim to provide direction and reference for more relevant researchers in the future.
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spelling pubmed-103081982023-06-30 The glymphatic system: a new perspective on brain diseases Ding, Zhao Fan, Xiaodi Zhang, Yehao Yao, Mingjiang Wang, Guangrui Dong, Yilei Liu, Jianxun Song, Wenting Front Aging Neurosci Neuroscience The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the endfeet of astrocytes, which can deliver nutrients and active substances to the brain parenchyma through periarterial cerebrospinal fluid (CSF) influx pathway and remove metabolic wastes through perivenous clearance routes. This paper summarizes the composition, overall fluid flow, solute transport, related diseases, affecting factors, and preclinical research methods of the glymphatic system. In doing so, we aim to provide direction and reference for more relevant researchers in the future. Frontiers Media S.A. 2023-06-15 /pmc/articles/PMC10308198/ /pubmed/37396658 http://dx.doi.org/10.3389/fnagi.2023.1179988 Text en Copyright © 2023 Ding, Fan, Zhang, Yao, Wang, Dong, Liu and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ding, Zhao
Fan, Xiaodi
Zhang, Yehao
Yao, Mingjiang
Wang, Guangrui
Dong, Yilei
Liu, Jianxun
Song, Wenting
The glymphatic system: a new perspective on brain diseases
title The glymphatic system: a new perspective on brain diseases
title_full The glymphatic system: a new perspective on brain diseases
title_fullStr The glymphatic system: a new perspective on brain diseases
title_full_unstemmed The glymphatic system: a new perspective on brain diseases
title_short The glymphatic system: a new perspective on brain diseases
title_sort glymphatic system: a new perspective on brain diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308198/
https://www.ncbi.nlm.nih.gov/pubmed/37396658
http://dx.doi.org/10.3389/fnagi.2023.1179988
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