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Calculating detection limits and uncertainty of reference-based deconvolution of whole-blood DNA methylation data
DNA methylation (DNAm)-based cell mixture deconvolution (CMD) has become a quintessential part of epigenome-wide association studies where DNAm is profiled in heterogeneous tissue types. Despite being introduced over a decade ago, detection limits, which represent the smallest fraction of a cell typ...
Autores principales: | Bell-Glenn, Shelby, Salas, Lucas A, Molinaro, Annette M, Butler, Rondi A, Christensen, Brock C, Kelsey, Karl T, Wiencke, John K, Koestler, Devin C |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308256/ https://www.ncbi.nlm.nih.gov/pubmed/37337720 http://dx.doi.org/10.2217/epi-2023-0006 |
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