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Sepsis-induced mitochondrial dysfunction: A narrative review
Sepsis represents a deranged and exaggerated systemic inflammatory response to infection and is associated with vascular and metabolic abnormalities that trigger systemic organic dysfunction. Mitochondrial function has been shown to be severely impaired during the early phase of critical illness, wi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308342/ https://www.ncbi.nlm.nih.gov/pubmed/37397587 http://dx.doi.org/10.5492/wjccm.v12.i3.139 |
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author | Nedel, Wagner Deutschendorf, Caroline Portela, Luis Valmor Cruz |
author_facet | Nedel, Wagner Deutschendorf, Caroline Portela, Luis Valmor Cruz |
author_sort | Nedel, Wagner |
collection | PubMed |
description | Sepsis represents a deranged and exaggerated systemic inflammatory response to infection and is associated with vascular and metabolic abnormalities that trigger systemic organic dysfunction. Mitochondrial function has been shown to be severely impaired during the early phase of critical illness, with a reduction in biogenesis, increased generation of reactive oxygen species and a decrease in adenosine triphosphate synthesis of up to 50%. Mitochondrial dysfunction can be assessed using mitochondrial DNA concentration and respirometry assays, particularly in peripheral mononuclear cells. Isolation of monocytes and lymphocytes seems to be the most promising strategy for measuring mitochondrial activity in clinical settings because of the ease of collection, sample processing, and clinical relevance of the association between metabolic alterations and deficient immune responses in mononuclear cells. Studies have reported alterations in these variables in patients with sepsis compared with healthy controls and non-septic patients. However, few studies have explored the association between mitochondrial dysfunction in immune mononuclear cells and unfavorable clinical outcomes. An improvement in mitochondrial parameters in sepsis could theoretically serve as a biomarker of clinical recovery and response to oxygen and vasopressor therapies as well as reveal unexplored pathophysiological mechanistic targets. These features highlight the need for further studies on mitochondrial metabolism in immune cells as a feasible tool to evaluate patients in intensive care settings. The evaluation of mitochondrial metabolism is a promising tool for the evaluation and management of critically ill patients, especially those with sepsis. In this article, we explore the pathophysiological aspects, main methods of measurement, and the main studies in this field. |
format | Online Article Text |
id | pubmed-10308342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-103083422023-06-30 Sepsis-induced mitochondrial dysfunction: A narrative review Nedel, Wagner Deutschendorf, Caroline Portela, Luis Valmor Cruz World J Crit Care Med Minireviews Sepsis represents a deranged and exaggerated systemic inflammatory response to infection and is associated with vascular and metabolic abnormalities that trigger systemic organic dysfunction. Mitochondrial function has been shown to be severely impaired during the early phase of critical illness, with a reduction in biogenesis, increased generation of reactive oxygen species and a decrease in adenosine triphosphate synthesis of up to 50%. Mitochondrial dysfunction can be assessed using mitochondrial DNA concentration and respirometry assays, particularly in peripheral mononuclear cells. Isolation of monocytes and lymphocytes seems to be the most promising strategy for measuring mitochondrial activity in clinical settings because of the ease of collection, sample processing, and clinical relevance of the association between metabolic alterations and deficient immune responses in mononuclear cells. Studies have reported alterations in these variables in patients with sepsis compared with healthy controls and non-septic patients. However, few studies have explored the association between mitochondrial dysfunction in immune mononuclear cells and unfavorable clinical outcomes. An improvement in mitochondrial parameters in sepsis could theoretically serve as a biomarker of clinical recovery and response to oxygen and vasopressor therapies as well as reveal unexplored pathophysiological mechanistic targets. These features highlight the need for further studies on mitochondrial metabolism in immune cells as a feasible tool to evaluate patients in intensive care settings. The evaluation of mitochondrial metabolism is a promising tool for the evaluation and management of critically ill patients, especially those with sepsis. In this article, we explore the pathophysiological aspects, main methods of measurement, and the main studies in this field. Baishideng Publishing Group Inc 2023-06-09 /pmc/articles/PMC10308342/ /pubmed/37397587 http://dx.doi.org/10.5492/wjccm.v12.i3.139 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews Nedel, Wagner Deutschendorf, Caroline Portela, Luis Valmor Cruz Sepsis-induced mitochondrial dysfunction: A narrative review |
title | Sepsis-induced mitochondrial dysfunction: A narrative review |
title_full | Sepsis-induced mitochondrial dysfunction: A narrative review |
title_fullStr | Sepsis-induced mitochondrial dysfunction: A narrative review |
title_full_unstemmed | Sepsis-induced mitochondrial dysfunction: A narrative review |
title_short | Sepsis-induced mitochondrial dysfunction: A narrative review |
title_sort | sepsis-induced mitochondrial dysfunction: a narrative review |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308342/ https://www.ncbi.nlm.nih.gov/pubmed/37397587 http://dx.doi.org/10.5492/wjccm.v12.i3.139 |
work_keys_str_mv | AT nedelwagner sepsisinducedmitochondrialdysfunctionanarrativereview AT deutschendorfcaroline sepsisinducedmitochondrialdysfunctionanarrativereview AT portelaluisvalmorcruz sepsisinducedmitochondrialdysfunctionanarrativereview |