Cargando…

Sepsis-induced mitochondrial dysfunction: A narrative review

Sepsis represents a deranged and exaggerated systemic inflammatory response to infection and is associated with vascular and metabolic abnormalities that trigger systemic organic dysfunction. Mitochondrial function has been shown to be severely impaired during the early phase of critical illness, wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Nedel, Wagner, Deutschendorf, Caroline, Portela, Luis Valmor Cruz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308342/
https://www.ncbi.nlm.nih.gov/pubmed/37397587
http://dx.doi.org/10.5492/wjccm.v12.i3.139
_version_ 1785066225397661696
author Nedel, Wagner
Deutschendorf, Caroline
Portela, Luis Valmor Cruz
author_facet Nedel, Wagner
Deutschendorf, Caroline
Portela, Luis Valmor Cruz
author_sort Nedel, Wagner
collection PubMed
description Sepsis represents a deranged and exaggerated systemic inflammatory response to infection and is associated with vascular and metabolic abnormalities that trigger systemic organic dysfunction. Mitochondrial function has been shown to be severely impaired during the early phase of critical illness, with a reduction in biogenesis, increased generation of reactive oxygen species and a decrease in adenosine triphosphate synthesis of up to 50%. Mitochondrial dysfunction can be assessed using mitochondrial DNA concentration and respirometry assays, particularly in peripheral mononuclear cells. Isolation of monocytes and lymphocytes seems to be the most promising strategy for measuring mitochondrial activity in clinical settings because of the ease of collection, sample processing, and clinical relevance of the association between metabolic alterations and deficient immune responses in mononuclear cells. Studies have reported alterations in these variables in patients with sepsis compared with healthy controls and non-septic patients. However, few studies have explored the association between mitochondrial dysfunction in immune mononuclear cells and unfavorable clinical outcomes. An improvement in mitochondrial parameters in sepsis could theoretically serve as a biomarker of clinical recovery and response to oxygen and vasopressor therapies as well as reveal unexplored pathophysiological mechanistic targets. These features highlight the need for further studies on mitochondrial metabolism in immune cells as a feasible tool to evaluate patients in intensive care settings. The evaluation of mitochondrial metabolism is a promising tool for the evaluation and management of critically ill patients, especially those with sepsis. In this article, we explore the pathophysiological aspects, main methods of measurement, and the main studies in this field.
format Online
Article
Text
id pubmed-10308342
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-103083422023-06-30 Sepsis-induced mitochondrial dysfunction: A narrative review Nedel, Wagner Deutschendorf, Caroline Portela, Luis Valmor Cruz World J Crit Care Med Minireviews Sepsis represents a deranged and exaggerated systemic inflammatory response to infection and is associated with vascular and metabolic abnormalities that trigger systemic organic dysfunction. Mitochondrial function has been shown to be severely impaired during the early phase of critical illness, with a reduction in biogenesis, increased generation of reactive oxygen species and a decrease in adenosine triphosphate synthesis of up to 50%. Mitochondrial dysfunction can be assessed using mitochondrial DNA concentration and respirometry assays, particularly in peripheral mononuclear cells. Isolation of monocytes and lymphocytes seems to be the most promising strategy for measuring mitochondrial activity in clinical settings because of the ease of collection, sample processing, and clinical relevance of the association between metabolic alterations and deficient immune responses in mononuclear cells. Studies have reported alterations in these variables in patients with sepsis compared with healthy controls and non-septic patients. However, few studies have explored the association between mitochondrial dysfunction in immune mononuclear cells and unfavorable clinical outcomes. An improvement in mitochondrial parameters in sepsis could theoretically serve as a biomarker of clinical recovery and response to oxygen and vasopressor therapies as well as reveal unexplored pathophysiological mechanistic targets. These features highlight the need for further studies on mitochondrial metabolism in immune cells as a feasible tool to evaluate patients in intensive care settings. The evaluation of mitochondrial metabolism is a promising tool for the evaluation and management of critically ill patients, especially those with sepsis. In this article, we explore the pathophysiological aspects, main methods of measurement, and the main studies in this field. Baishideng Publishing Group Inc 2023-06-09 /pmc/articles/PMC10308342/ /pubmed/37397587 http://dx.doi.org/10.5492/wjccm.v12.i3.139 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Nedel, Wagner
Deutschendorf, Caroline
Portela, Luis Valmor Cruz
Sepsis-induced mitochondrial dysfunction: A narrative review
title Sepsis-induced mitochondrial dysfunction: A narrative review
title_full Sepsis-induced mitochondrial dysfunction: A narrative review
title_fullStr Sepsis-induced mitochondrial dysfunction: A narrative review
title_full_unstemmed Sepsis-induced mitochondrial dysfunction: A narrative review
title_short Sepsis-induced mitochondrial dysfunction: A narrative review
title_sort sepsis-induced mitochondrial dysfunction: a narrative review
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308342/
https://www.ncbi.nlm.nih.gov/pubmed/37397587
http://dx.doi.org/10.5492/wjccm.v12.i3.139
work_keys_str_mv AT nedelwagner sepsisinducedmitochondrialdysfunctionanarrativereview
AT deutschendorfcaroline sepsisinducedmitochondrialdysfunctionanarrativereview
AT portelaluisvalmorcruz sepsisinducedmitochondrialdysfunctionanarrativereview