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Immune synaptopathies: how maternal immune activation impacts synaptic function during development
In the last two decades, the term synaptopathy has been largely used to underline the concept that impairments of synaptic structure and function are the major determinant of brain disorders, including neurodevelopmental disorders. This notion emerged from the progress made in understanding the gene...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308362/ https://www.ncbi.nlm.nih.gov/pubmed/37161785 http://dx.doi.org/10.15252/embj.2023113796 |
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author | Matteoli, Michela Pozzi, Davide Fossati, Matteo Menna, Elisabetta |
author_facet | Matteoli, Michela Pozzi, Davide Fossati, Matteo Menna, Elisabetta |
author_sort | Matteoli, Michela |
collection | PubMed |
description | In the last two decades, the term synaptopathy has been largely used to underline the concept that impairments of synaptic structure and function are the major determinant of brain disorders, including neurodevelopmental disorders. This notion emerged from the progress made in understanding the genetic architecture of neurodevelopmental disorders, which highlighted the convergence of genetic risk factors onto molecular pathways specifically localized at the synapse. However, the multifactorial origin of these disorders also indicated the key contribution of environmental factors. It is well recognized that inflammation is a risk factor for neurodevelopmental disorders, and several immune molecules critically contribute to synaptic dysfunction. In the present review, we highlight this concept, which we define by the term “immune‐synaptopathy,” and we discuss recent evidence suggesting a bi‐directional link between the genetic architecture of individuals and maternal activation of the immune system in modulating brain developmental trajectories in health and disease. |
format | Online Article Text |
id | pubmed-10308362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103083622023-06-30 Immune synaptopathies: how maternal immune activation impacts synaptic function during development Matteoli, Michela Pozzi, Davide Fossati, Matteo Menna, Elisabetta EMBO J Review In the last two decades, the term synaptopathy has been largely used to underline the concept that impairments of synaptic structure and function are the major determinant of brain disorders, including neurodevelopmental disorders. This notion emerged from the progress made in understanding the genetic architecture of neurodevelopmental disorders, which highlighted the convergence of genetic risk factors onto molecular pathways specifically localized at the synapse. However, the multifactorial origin of these disorders also indicated the key contribution of environmental factors. It is well recognized that inflammation is a risk factor for neurodevelopmental disorders, and several immune molecules critically contribute to synaptic dysfunction. In the present review, we highlight this concept, which we define by the term “immune‐synaptopathy,” and we discuss recent evidence suggesting a bi‐directional link between the genetic architecture of individuals and maternal activation of the immune system in modulating brain developmental trajectories in health and disease. John Wiley and Sons Inc. 2023-05-10 /pmc/articles/PMC10308362/ /pubmed/37161785 http://dx.doi.org/10.15252/embj.2023113796 Text en © 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Matteoli, Michela Pozzi, Davide Fossati, Matteo Menna, Elisabetta Immune synaptopathies: how maternal immune activation impacts synaptic function during development |
title | Immune synaptopathies: how maternal immune activation impacts synaptic function during development |
title_full | Immune synaptopathies: how maternal immune activation impacts synaptic function during development |
title_fullStr | Immune synaptopathies: how maternal immune activation impacts synaptic function during development |
title_full_unstemmed | Immune synaptopathies: how maternal immune activation impacts synaptic function during development |
title_short | Immune synaptopathies: how maternal immune activation impacts synaptic function during development |
title_sort | immune synaptopathies: how maternal immune activation impacts synaptic function during development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308362/ https://www.ncbi.nlm.nih.gov/pubmed/37161785 http://dx.doi.org/10.15252/embj.2023113796 |
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