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Acupuncture for premature ejaculation: a systematic review and meta-analysis
BACKGROUND: Although acupuncture is widely used to treat premature ejaculation (PE), its effectiveness remains highly controversial. AIM: To evaluate the efficacy and safety of acupuncture on PE. METHODS: According to the relevant keywords, 11 major English and Chinese databases were searched for ra...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308367/ https://www.ncbi.nlm.nih.gov/pubmed/37397031 http://dx.doi.org/10.1093/sexmed/qfad034 |
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author | Zhang, Hui Colonnello, Elena Sansone, Andrea Wang, Fu Guo, Jun Wang, Chunling Zhang, Yan Jannini, Emmanuele A |
author_facet | Zhang, Hui Colonnello, Elena Sansone, Andrea Wang, Fu Guo, Jun Wang, Chunling Zhang, Yan Jannini, Emmanuele A |
author_sort | Zhang, Hui |
collection | PubMed |
description | BACKGROUND: Although acupuncture is widely used to treat premature ejaculation (PE), its effectiveness remains highly controversial. AIM: To evaluate the efficacy and safety of acupuncture on PE. METHODS: According to the relevant keywords, 11 major English and Chinese databases were searched for randomized controlled trials (RCTs) of acupuncture alone or in combination with other treatments for PE. The quality of evidence across studies was assessed by the GRADEpro tool. OUTCOMES: Study outcome measures included the intravaginal ejaculation latency time (IELT), the Premature Ejaculation Diagnostic Tool (PEDT), the Chinese Index of Premature Ejaculation–5 (CIPE-5), treatment success rate, and adverse events. RESULTS: Seven trials were included in this review for a total of 603 participants. A low quality of evidence suggests that it is not possible to determine whether acupuncture, as compared with a selective serotonin reuptake inhibitor, has an advantage in improving the IELT (standardized mean difference [SMD], −1.75; 95% CI, −6.12 to 2.63; P = .43, I(2) = 98%), PEDT scores (SMD, 0.32; 95% CI, −0.68 to 1.32; P = .53, I(2) = 85%), and treatment success rate (risk ratio, 0.69; 95% CI, 0.41-1.14; P = .15). However, participants receiving acupuncture had a lower CIPE-5 (SMD, −1.06; 95% CI, −1.68 to −0.44; P < .01). As compared with sham acupuncture, acupuncture significantly improved the IELT (SMD, 1.47; 95% CI, 1.01-1.92; P < .01, I(2) = 0%) and PEDT scores (SMD, −1.23; 95% CI, −1.78 to −0.67; P < .01, I(2) = 37%). When compared with other treatments alone, a combined treatment with acupuncture can significantly improve the IELT (SMD, 7.06; 95% CI, 2.53-11.59; P < .01, I(2) = 97%), CIPE-5 (SMD, 0.84; 95% CI, 0.45-1.22; P < .01, I(2) = 0%), and treatment success rate (SMD, 1.60; 95% CI, 1.18-2.16; P < .01, I(2) = 53). CLINICAL IMPLICATIONS: The results suggest a significant effect of acupuncture in the treatment of certain important indicators of PE; however, this finding needs to be treated with caution because of the quality of the RCTs included. STRENGTHS AND LIMITATIONS: Comprehensive inclusion of available RCTs has been performed. However, limitations include a low number of studies and a lack of detailed information to allow subgroup analysis. CONCLUSION: The present systematic review and meta-analysis show that acupuncture has a significant effect on several subjective PE parameters, such as improving the feeling of control over ejaculation and distress, particularly when used in an integrated way. However, due to the low quality of evidence, acupuncture still needs larger well-designed RCTs to be confirmed. |
format | Online Article Text |
id | pubmed-10308367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103083672023-06-30 Acupuncture for premature ejaculation: a systematic review and meta-analysis Zhang, Hui Colonnello, Elena Sansone, Andrea Wang, Fu Guo, Jun Wang, Chunling Zhang, Yan Jannini, Emmanuele A Sex Med Review BACKGROUND: Although acupuncture is widely used to treat premature ejaculation (PE), its effectiveness remains highly controversial. AIM: To evaluate the efficacy and safety of acupuncture on PE. METHODS: According to the relevant keywords, 11 major English and Chinese databases were searched for randomized controlled trials (RCTs) of acupuncture alone or in combination with other treatments for PE. The quality of evidence across studies was assessed by the GRADEpro tool. OUTCOMES: Study outcome measures included the intravaginal ejaculation latency time (IELT), the Premature Ejaculation Diagnostic Tool (PEDT), the Chinese Index of Premature Ejaculation–5 (CIPE-5), treatment success rate, and adverse events. RESULTS: Seven trials were included in this review for a total of 603 participants. A low quality of evidence suggests that it is not possible to determine whether acupuncture, as compared with a selective serotonin reuptake inhibitor, has an advantage in improving the IELT (standardized mean difference [SMD], −1.75; 95% CI, −6.12 to 2.63; P = .43, I(2) = 98%), PEDT scores (SMD, 0.32; 95% CI, −0.68 to 1.32; P = .53, I(2) = 85%), and treatment success rate (risk ratio, 0.69; 95% CI, 0.41-1.14; P = .15). However, participants receiving acupuncture had a lower CIPE-5 (SMD, −1.06; 95% CI, −1.68 to −0.44; P < .01). As compared with sham acupuncture, acupuncture significantly improved the IELT (SMD, 1.47; 95% CI, 1.01-1.92; P < .01, I(2) = 0%) and PEDT scores (SMD, −1.23; 95% CI, −1.78 to −0.67; P < .01, I(2) = 37%). When compared with other treatments alone, a combined treatment with acupuncture can significantly improve the IELT (SMD, 7.06; 95% CI, 2.53-11.59; P < .01, I(2) = 97%), CIPE-5 (SMD, 0.84; 95% CI, 0.45-1.22; P < .01, I(2) = 0%), and treatment success rate (SMD, 1.60; 95% CI, 1.18-2.16; P < .01, I(2) = 53). CLINICAL IMPLICATIONS: The results suggest a significant effect of acupuncture in the treatment of certain important indicators of PE; however, this finding needs to be treated with caution because of the quality of the RCTs included. STRENGTHS AND LIMITATIONS: Comprehensive inclusion of available RCTs has been performed. However, limitations include a low number of studies and a lack of detailed information to allow subgroup analysis. CONCLUSION: The present systematic review and meta-analysis show that acupuncture has a significant effect on several subjective PE parameters, such as improving the feeling of control over ejaculation and distress, particularly when used in an integrated way. However, due to the low quality of evidence, acupuncture still needs larger well-designed RCTs to be confirmed. Oxford University Press 2023-06-29 /pmc/articles/PMC10308367/ /pubmed/37397031 http://dx.doi.org/10.1093/sexmed/qfad034 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of The International Society of Sexual Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Review Zhang, Hui Colonnello, Elena Sansone, Andrea Wang, Fu Guo, Jun Wang, Chunling Zhang, Yan Jannini, Emmanuele A Acupuncture for premature ejaculation: a systematic review and meta-analysis |
title | Acupuncture for premature ejaculation: a systematic review and meta-analysis |
title_full | Acupuncture for premature ejaculation: a systematic review and meta-analysis |
title_fullStr | Acupuncture for premature ejaculation: a systematic review and meta-analysis |
title_full_unstemmed | Acupuncture for premature ejaculation: a systematic review and meta-analysis |
title_short | Acupuncture for premature ejaculation: a systematic review and meta-analysis |
title_sort | acupuncture for premature ejaculation: a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308367/ https://www.ncbi.nlm.nih.gov/pubmed/37397031 http://dx.doi.org/10.1093/sexmed/qfad034 |
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