Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1‐SV2 plasma membrane nanocluster for synaptic vesicle entry

The unique nerve terminal targeting of botulinum neurotoxin type A (BoNT/A) is due to its capacity to bind two receptors on the neuronal plasma membrane: polysialoganglioside (PSG) and synaptic vesicle glycoprotein 2 (SV2). Whether and how PSGs and SV2 may coordinate other proteins for BoNT/A recrui...

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Detalles Bibliográficos
Autores principales: Joensuu, Merja, Syed, Parnayan, Saber, Saber H, Lanoue, Vanessa, Wallis, Tristan P, Rae, James, Blum, Ailisa, Gormal, Rachel S, Small, Christopher, Sanders, Shanley, Jiang, Anmin, Mahrhold, Stefan, Krez, Nadja, Cousin, Michael A, Cooper‐White, Ruby, Cooper‐White, Justin J, Collins, Brett M, Parton, Robert G, Balistreri, Giuseppe, Rummel, Andreas, Meunier, Frédéric A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308369/
https://www.ncbi.nlm.nih.gov/pubmed/37226896
http://dx.doi.org/10.15252/embj.2022112095

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