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Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center

BACKGROUND: Lipodystrophy (LH) is one of the most common complications of subcutaneous insulin injection. Many factors are incriminated in the evolution of LH in children with diabetes type 1 (T1DM). LH may affect insulin absorption in skin areas involved, resulting in negative impact on blood gluco...

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Autores principales: Elsayed, Shaymaa, Soliman, Ashraf, De Sanctis, Vincenzo, Fawzy, Dina, Ahmed, Shaymaa, Alaaraj, Nada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308467/
https://www.ncbi.nlm.nih.gov/pubmed/37326270
http://dx.doi.org/10.23750/abm.v94i3.14117
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author Elsayed, Shaymaa
Soliman, Ashraf
De Sanctis, Vincenzo
Fawzy, Dina
Ahmed, Shaymaa
Alaaraj, Nada
author_facet Elsayed, Shaymaa
Soliman, Ashraf
De Sanctis, Vincenzo
Fawzy, Dina
Ahmed, Shaymaa
Alaaraj, Nada
author_sort Elsayed, Shaymaa
collection PubMed
description BACKGROUND: Lipodystrophy (LH) is one of the most common complications of subcutaneous insulin injection. Many factors are incriminated in the evolution of LH in children with diabetes type 1 (T1DM). LH may affect insulin absorption in skin areas involved, resulting in negative impact on blood glucose levels and glycemic variability. PATIENTS AND METHODS: We calculated evaluated the prevalence of LH in relation to possible clinical factors associated with the development of LH in a cohort of children (n =115) with T1DM using insulin pens or syringes and we studied possible predisposing factors including their age, duration of T1DM, injection technique, insulin dose/kg, degree of pain perception, and HbA(1c) level. RESULTS: In our cross-sectional study, 84% of patients were using pens for insulin injection and 52.2 % of them were rotating the site of injection on daily basis. 27 % did not experience pain during injection while 6 % had the worst hurt. 49.5 % had clinically detectable LH. Those with LH had higher HbA(1c) level and more unexplained hypoglycemic events compared to those without LH (P: 0.058). The hypertrophied site was related to the preferred site of injection which was the arms in 71.9 % of the cases. Children who had LH were older with longer duration of T1DM, rotating sites of injection less frequently and were more frequently reusing needles compared to children without LH (P: < 0.05). CONCLUSION: Improper insulin injection technique, older age, and longer duration of T1DM were associated with LH. Proper education of patients and their parents must include correct injection techniques, rotating injection sites, and minimal reuse of needles. (www.actabiomedica.it)
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spelling pubmed-103084672023-06-30 Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center Elsayed, Shaymaa Soliman, Ashraf De Sanctis, Vincenzo Fawzy, Dina Ahmed, Shaymaa Alaaraj, Nada Acta Biomed Pediatrics and Adolescent Medicine BACKGROUND: Lipodystrophy (LH) is one of the most common complications of subcutaneous insulin injection. Many factors are incriminated in the evolution of LH in children with diabetes type 1 (T1DM). LH may affect insulin absorption in skin areas involved, resulting in negative impact on blood glucose levels and glycemic variability. PATIENTS AND METHODS: We calculated evaluated the prevalence of LH in relation to possible clinical factors associated with the development of LH in a cohort of children (n =115) with T1DM using insulin pens or syringes and we studied possible predisposing factors including their age, duration of T1DM, injection technique, insulin dose/kg, degree of pain perception, and HbA(1c) level. RESULTS: In our cross-sectional study, 84% of patients were using pens for insulin injection and 52.2 % of them were rotating the site of injection on daily basis. 27 % did not experience pain during injection while 6 % had the worst hurt. 49.5 % had clinically detectable LH. Those with LH had higher HbA(1c) level and more unexplained hypoglycemic events compared to those without LH (P: 0.058). The hypertrophied site was related to the preferred site of injection which was the arms in 71.9 % of the cases. Children who had LH were older with longer duration of T1DM, rotating sites of injection less frequently and were more frequently reusing needles compared to children without LH (P: < 0.05). CONCLUSION: Improper insulin injection technique, older age, and longer duration of T1DM were associated with LH. Proper education of patients and their parents must include correct injection techniques, rotating injection sites, and minimal reuse of needles. (www.actabiomedica.it) Mattioli 1885 2023 2023-06-14 /pmc/articles/PMC10308467/ /pubmed/37326270 http://dx.doi.org/10.23750/abm.v94i3.14117 Text en Copyright: © 2023 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Pediatrics and Adolescent Medicine
Elsayed, Shaymaa
Soliman, Ashraf
De Sanctis, Vincenzo
Fawzy, Dina
Ahmed, Shaymaa
Alaaraj, Nada
Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center
title Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center
title_full Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center
title_fullStr Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center
title_full_unstemmed Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center
title_short Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center
title_sort insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (t1dm) in a tertiary care egyptian center
topic Pediatrics and Adolescent Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308467/
https://www.ncbi.nlm.nih.gov/pubmed/37326270
http://dx.doi.org/10.23750/abm.v94i3.14117
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