Design of LNA Analogues Using a Combined Density Functional Theory and Molecular Dynamics Approach for RNA Therapeutics

[Image: see text] Antisense therapeutics treat a wide spectrum of diseases, many of which cannot be addressed with the current drug technologies. In the quest to design better antisense oligonucleotide drugs, we propose five novel LNA analogues (A1–A5) for modifying antisense oligonucleotides and es...

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Detalles Bibliográficos
Autores principales: Dowerah, Dikshita, V. N. Uppuladinne, Mallikarjunachari, Sarma, Plaban J., Biswakarma, Nishant, Sonavane, Uddhavesh B., Joshi, Rajendra R., Ray, Suvendra K., Namsa, Nima D., Deka, Ramesh Ch.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308574/
https://www.ncbi.nlm.nih.gov/pubmed/37396274
http://dx.doi.org/10.1021/acsomega.2c07860

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